ROS1

Entrez Summary: This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008].
UniProt Summary: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of phosphate transport
peptidyl-tyrosine autophosphorylation
columnar/cuboidal epithelial cell development
transmembrane receptor protein tyrosine kinase activity
protein phosphatase binding
protein tyrosine kinase activity
regulation of anion transport
columnar/cuboidal epithelial cell differentiation
regulation of TOR signaling
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
epithelial cell development
protein autophosphorylation
receptor complex
regulation of ERK1 and ERK2 cascade
signal transduction by protein phosphorylation
regulation of cell growth
transmembrane receptor protein tyrosine kinase signaling pathway
spermatogenesis
cell population proliferation
male gamete generation
cell surface
regulation of growth
epithelial cell differentiation
gamete generation
perinuclear region of cytoplasm
regulation of ion transport
enzyme linked receptor protein signaling pathway
regulation of MAPK cascade
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
peptidyl-amino acid modification
protein phosphorylation
multi-organism reproductive process
epithelium development
phosphorylation
integral component of plasma membrane
reproductive process
reproduction