RPH3A

Entrez Summary: The protein encoded by this gene is thought to be an effector for RAB3A, which is a small G protein that acts in the late stages of neurotransmitter exocytosis. The encoded protein may be involved in neurotransmitter release and synaptic vesicle traffic. [provided by RefSeq, Dec 2016].
UniProt Summary: Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Atovaquone 15μM R08 exp451	-2.08
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.74
Alpha-Amanitin 0.5μM R00 exp5	2.01

RPH3A effect N
C2

spontaneous neurotransmitter secretion
spontaneous synaptic transmission
selenium binding
phosphate ion binding
phosphatidylinositol phosphate binding
inositol 1,4,5 trisphosphate binding
calcium-dependent phospholipid binding
extrinsic component of membrane
synaptic vesicle membrane
phosphatidylinositol-4,5-bisphosphate binding
secretory granule
neurotransmitter secretion
signal release from synapse
synaptic vesicle
dendritic spine
Rab GTPase binding
signal release
neurotransmitter transport
postsynaptic membrane
protein-containing complex binding
synapse
neuron projection
regulation of neurotransmitter levels
chemical synaptic transmission
anterograde trans-synaptic signaling
trans-synaptic signaling
synaptic signaling
cell junction
protein-containing complex
calcium ion binding
zinc ion binding
Golgi apparatus
intracellular protein transport
secretion by cell
export from cell
cell-cell signaling
secretion
protein transport
intracellular transport
peptide transport