RPH3AL

Entrez Summary: The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010].
UniProt Summary: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15003533}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

LIM domain binding
transport vesicle membrane
regulation of calcium ion-dependent exocytosis
negative regulation of G protein-coupled receptor signaling pathway
positive regulation of insulin secretion
cytoskeletal protein binding
positive regulation of peptide hormone secretion
secretory granule membrane
positive regulation of hormone secretion
regulation of G protein-coupled receptor signaling pathway
Rab GTPase binding
regulation of regulated secretory pathway
regulation of insulin secretion
glucose homeostasis
carbohydrate homeostasis
regulation of peptide hormone secretion
regulation of exocytosis
regulation of hormone secretion
positive regulation of protein secretion
positive regulation of peptide secretion
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion
regulation of hormone levels
regulation of vesicle-mediated transport
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
exocytosis
regulation of secretion
positive regulation of transport
intracellular protein transport
secretion by cell
response to drug
regulation of protein localization
export from cell