RPL30 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL30 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL30
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L30
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6156|6156]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62888|P62888]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL30&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL30|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180467|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L7Ae|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polysomal ribosome|
|killing of cells of other organism|
|disruption of cells of other organism|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|cytosolic large ribosomal subunit|
|cytoplasmic translation|
|defense response to Gram-negative bacterium|
|cell killing|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|antimicrobial humoral response|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|modification of morphology or physiology of other organism|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|postsynaptic density|
|establishment of protein localization to membrane|
|defense response to bacterium|
|humoral immune response|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|response to bacterium|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|defense response to other organism|
|intracellular protein transport|
|macromolecule catabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.8|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.53|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.06|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.91|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.9|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.87|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.82|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.79|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.76|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.8|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.84|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.84|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.85|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.85|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.86|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|1.89|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.89|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.95|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.96|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.97|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.98|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.04|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.04|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.06|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.1|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.23|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.25|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|2.25|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2.31|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.36|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.37|
|[[:results:exp124|GSK343 3μM R03 exp124]]|2.42|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.42|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.44|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|2.53|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.56|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|2.62|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|2.79|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.85|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.526|
|[[:human genes:t:tceb3c|TCEB3C]]|0.522|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.51|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.499|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.499|
|[[:human genes:c:cacna1a|CACNA1A]]|0.498|
|[[:human genes:p:psmb4|PSMB4]]|0.487|
|[[:human genes:o:orc1|ORC1]]|0.487|
|[[:human genes:z:zfand5|ZFAND5]]|0.486|
|[[:human genes:r:rps12|RPS12]]|0.485|
|[[:human genes:d:disp2|DISP2]]|0.485|
|[[:human genes:r:rpl34|RPL34]]|0.482|
|[[:human genes:c:chd4|CHD4]]|0.475|
|[[:human genes:p:psmc2|PSMC2]]|0.474|
|[[:human genes:n:narfl|NARFL]]|0.472|
|[[:human genes:r:rps28|RPS28]]|0.47|
|[[:human genes:r:rpl6|RPL6]]|0.469|
|[[:human genes:r:ranbp2|RANBP2]]|0.466|
|[[:human genes:v:vasn|VASN]]|0.465|
|[[:human genes:t:ttc31|TTC31]]|0.458|
|[[:human genes:c:copg1|COPG1]]|0.456|
|[[:human genes:p:pola1|POLA1]]|0.454|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.453|
|[[:human genes:r:rad51|RAD51]]|0.452|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.45|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.447|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.447|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.446|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.446|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.446|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.445|
|[[:human genes:c:cln6|CLN6]]|0.444|
|[[:human genes:r:rpl9|RPL9]]|0.444|
|[[:human genes:n:napa|NAPA]]|0.443|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.441|
|[[:human genes:r:rbbp5|RBBP5]]|0.438|
|[[:human genes:g:gosr2|GOSR2]]|0.436|
|[[:human genes:s:supt6h|SUPT6H]]|0.435|
|[[:human genes:s:smg7|SMG7]]|0.434|
|[[:human genes:f:fam25b|FAM25B]]|0.433|
|[[:human genes:r:rpl17|RPL17]]|0.432|
|[[:human genes:f:fam160a1|FAM160A1]]|0.431|
|[[:human genes:r:rps14|RPS14]]|0.43|
|[[:human genes:c:copb1|COPB1]]|0.43|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.427|
|[[:human genes:r:rps19|RPS19]]|0.427|
|[[:human genes:p:psmd11|PSMD11]]|0.425|
|[[:human genes:t:ticrr|TICRR]]|0.425|
|[[:human genes:d:ddx56|DDX56]]|0.425|
|[[:human genes:r:rps5|RPS5]]|0.424|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.423|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.423|
|[[:human genes:m:mt1e|MT1E]]|0.423|
|[[:human genes:c:cactin|CACTIN]]|0.422|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.421|
|[[:human genes:t:terf2|TERF2]]|0.421|
|[[:human genes:r:rrn3|RRN3]]|0.421|
|[[:human genes:t:top1mt|TOP1MT]]|0.42|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.419|
|[[:human genes:d:ddtl|DDTL]]|0.419|
|[[:human genes:a:arcn1|ARCN1]]|0.419|
|[[:human genes:p:pan3|PAN3]]|0.418|
|[[:human genes:r:rps6|RPS6]]|0.418|
|[[:human genes:n:nsf|NSF]]|0.417|
|[[:human genes:v:vps28|VPS28]]|0.416|
|[[:human genes:a:aatf|AATF]]|0.416|
|[[:human genes:t:traip|TRAIP]]|0.416|
|[[:human genes:m:myb|MYB]]|0.416|
|[[:human genes:p:psmd3|PSMD3]]|0.415|
|[[:human genes:n:nup153|NUP153]]|0.415|
|[[:human genes:p:psmd1|PSMD1]]|0.414|
|[[:human genes:p:psma7|PSMA7]]|0.414|
|[[:human genes:r:rffl|RFFL]]|0.414|
|[[:human genes:m:myo1h|MYO1H]]|0.414|
|[[:human genes:a:aqr|AQR]]|0.413|
|[[:human genes:n:numa1|NUMA1]]|0.413|
|[[:human genes:h:hap1|HAP1]]|0.413|
|[[:human genes:r:rplp1|RPLP1]]|0.413|
|[[:human genes:e:exosc9|EXOSC9]]|0.412|
|[[:human genes:n:nol12|NOL12]]|0.412|
|[[:human genes:e:exosc3|EXOSC3]]|0.412|
|[[:human genes:u:usp37|USP37]]|0.412|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.41|
|[[:human genes:s:smg1|SMG1]]|0.41|
|[[:human genes:n:nop16|NOP16]]|0.41|
|[[:human genes:h:hivep3|HIVEP3]]|0.409|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.408|
|[[:human genes:e:exosc5|EXOSC5]]|0.407|
|[[:human genes:k:kif3c|KIF3C]]|0.407|
|[[:human genes:c:chaf1a|CHAF1A]]|0.407|
|[[:human genes:e:eif3k|EIF3K]]|0.407|
|[[:human genes:c:cgb2|CGB2]]|0.406|
|[[:human genes:s:slc6a17|SLC6A17]]|0.406|
|[[:human genes:u:utp3|UTP3]]|0.406|
|[[:human genes:c:cbwd5|CBWD5]]|0.406|
|[[:human genes:c:cdc45|CDC45]]|0.406|
|[[:human genes:z:znf106|ZNF106]]|0.405|
|[[:human genes:c:c14orf93|C14orf93]]|0.405|
|[[:human genes:b:brd2|BRD2]]|0.405|
|[[:human genes:a:atp1a3|ATP1A3]]|0.404|
|[[:human genes:r:rpl14|RPL14]]|0.404|
|[[:human genes:p:psma6|PSMA6]]|0.404|
|[[:human genes:s:snx15|SNX15]]|0.403|
|[[:human genes:c:ctage9|CTAGE9]]|0.403|
|[[:human genes:i:iscu|ISCU]]|0.403|
|[[:human genes:r:rfpl3|RFPL3]]|0.402|
|[[:human genes:c:cep192|CEP192]]|0.402|
|[[:human genes:r:rps2|RPS2]]|0.402|
|[[:human genes:r:rrp15|RRP15]]|0.402|
|[[:human genes:r:rrp1|RRP1]]|0.401|
|[[:human genes:c:cbwd3|CBWD3]]|0.4|
|[[:human genes:a:ankle1|ANKLE1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 34/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|2/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|3/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 480
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL30 Expression in NALM6 Cells: 8.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>