RPL30

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
AICAR 240μM R05 exp211	-2.8
UM0129480 7μM R02 exp85	-2.53
Nocodazole 0.2μM R02 exp64	-2.06
DABN racemic mixture R03 exp93	-1.91
NFN1 1μM R03 exp100	-1.9
Thimerosal 0.85μM R08 exp529	-1.87
THZ1 0.06μM R08 exp531	-1.82
SNS-032 15μM R08 exp443	-1.79
Atovaquone 15μM R08 exp451	-1.76
PFI-2 4μM R05 exp239	1.8
Quinacrine 2.5μM R03 exp146	1.84
Wortmannin 0.5μM R00 exp37	1.84
Colchicine 0.009μM R05 exp215	1.85
GSK2606414 1μM R05 exp236	1.85
Nocodazole 0.02μM R00 exp23	1.86
Aphidicolin 0.04μM R06 exp263	1.89
L-BMAA 500 to 750μM on day4 R04 exp185	1.89
VHL-ligand-1 20μM R07 exp421	1.95
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.96
UM131593 0.1μM R01 exp58	1.97
TRAIL 50ng/ml R00 exp36	1.98
Rapamycin 2μM R07 exp306	2.04
Temozolomide 200μM R04 exp189	2.04
HMS-I2 1μM R06 exp286	2.06
Cycloheximide 0.2μM R00 exp15	2.1
Parthenolide 2.5μM R05 exp238	2.23
Apcin 50 to 100μM on day4 R04 exp176	2.25
Dimethyloxaloylglycine 11μM R07 exp314	2.25
Menadione 5μM R06 exp292	2.31
Nifuroxazide 5μM R03 exp102	2.36
BI-2536 0.0042μM R03 exp95	2.37
GSK343 3μM R03 exp124	2.42
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.42
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.44
NFN1 0.4μM R03 exp99	2.53
Ribavirin 10 to 15μM on day4 R04 exp160	2.56
TGF-beta1 44ng/ml R08 exp528	2.62
Vinorelbine 0.001μM R05 exp249	2.79
BI-6727 0.0125μM R03 exp97	2.85
Tunicamycin 0.04μM R07 exp418	3

Global Fraction of Cell Lines Where Essential: 34/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	2/26
breast	2/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	3/21
liver	0/20
lung	4/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	2/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

polysomal ribosome
killing of cells of other organism
disruption of cells of other organism
antimicrobial humoral immune response mediated by antimicrobial peptide
cytosolic large ribosomal subunit
cytoplasmic translation
defense response to Gram-negative bacterium
cell killing
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
antimicrobial humoral response
establishment of protein localization to endoplasmic reticulum
viral transcription
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
viral gene expression
protein localization to endoplasmic reticulum
translational initiation
modification of morphology or physiology of other organism
protein targeting to membrane
structural constituent of ribosome
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
RNA catabolic process
postsynaptic density
establishment of protein localization to membrane
defense response to bacterium
humoral immune response
protein targeting
nucleobase-containing compound catabolic process
translation
peptide biosynthetic process
focal adhesion
establishment of protein localization to organelle
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
protein localization to membrane
organic cyclic compound catabolic process
amide biosynthetic process