RPRD1B [The Human Chemical-Genetic Interaction Map Project]

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======= RPRD1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPRD1B
  * **<color #00a2e8>Official Name</color>**: regulation of nuclear pre-mRNA domain containing 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58490|58490]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQG5|Q9NQG5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPRD1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPRD1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614694|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF618|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dephosphorylation of RNA polymerase II C-terminal domain|
|RNA polymerase II, holoenzyme|
|RNA polymerase II complex binding|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|mRNA 3-end processing|
|ncRNA transcription|
|RNA 3-end processing|
|protein dephosphorylation|
|dephosphorylation|
|mRNA processing|
|transcription by RNA polymerase II|
|centrosome|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|regulation of cell cycle process|
|RNA processing|
|positive regulation of cell population proliferation|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.43|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.33|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.27|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.15|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.11|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.1|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.08|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.06|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.97|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.73|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.79|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.82|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.92|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.02|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.04|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.13|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.15|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.16|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.18|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.27|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.33|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|3.33|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|4.62|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|5.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:ttc14|TTC14]]|0.53|
|[[:human genes:f:fam58a|FAM58A]]|0.528|
|[[:human genes:c:ccnk|CCNK]]|0.477|
|[[:human genes:r:rprd2|RPRD2]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 52/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|4/25|
|breast|2/33|
|central nervous system|9/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|2/14|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/7|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2124
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPRD1B Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>