RPRD1B

Entrez Summary: N/A
UniProt Summary: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.225μM R08 exp444	-2.43
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.33
Olaparib 4μM R08 exp512	-2.27
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.15
Rucaparib 6.5μM R08 exp520	-2.11
Methotrexate 0.01μM R08 exp501	-2.1
LLY-284 2.6μM R06 exp291	-2.08
THZ531 0.11μM R07 exp409	-2.06
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.97
CoCl2 18μM R07 exp346	1.73
5-Fluorouracil 20μM R00 exp2	1.79
INK128 0.2μM R02 exp70	1.82
Bafilomycin-A1 0.009μM R08 exp454	1.92
Rapamycin 2μM R07 exp306	2.02
Rapamycin 10μM R00 exp30	2.04
Cerivastatin 0.15μM R05 exp226	2.13
Bortezomib 0.005μM R00 exp6	2.15
Trametinib 10μM R02 exp83	2.16
Bisphenol A 100μM R06 exp269	2.18
All-trans-Retinoic-Acid 40μM R07 exp334	2.27
Fluvastatin 2.2μM R06 exp282	3.33
Thapsigargin 0.005μM R07 exp407	3.33
I-BRD9 4μM R07 exp365	4.62
Tubacin 1.6μM R07 exp416	5.99

Global Fraction of Cell Lines Where Essential: 52/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	2/28
bone	4/25
breast	2/33
central nervous system	9/56
cervix	0/4
colorectal	0/17
esophagus	2/13
fibroblast	0/1
gastric	0/15
kidney	1/21
liver	0/20
lung	3/75
lymphocyte	2/14
ovary	1/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	1/7
thyroid	1/2
upper aerodigestive	4/22
urinary tract	1/29
uterus	0/5

Expression Distribution

dephosphorylation of RNA polymerase II C-terminal domain
RNA polymerase II, holoenzyme
RNA polymerase II complex binding
snRNA transcription by RNA polymerase II
snRNA transcription
mRNA 3-end processing
ncRNA transcription
RNA 3-end processing
protein dephosphorylation
dephosphorylation
mRNA processing
transcription by RNA polymerase II
centrosome
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
regulation of cell cycle process
RNA processing
positive regulation of cell population proliferation
identical protein binding
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
regulation of cell population proliferation
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression