RPS6KA4
Gene Information
- Official Symbol: RPS6KA4
- Official Name: ribosomal protein S6 kinase A4
- Aliases and Previous Symbols: N/A
- Entrez ID: 8986
- UniProt: O75676
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase C |
| Pkinase Tyr |
| Pkinase |
GO Terms
| histone H3-S28 phosphorylation |
| histone H3-S10 phosphorylation |
| ribosomal protein S6 kinase activity |
| positive regulation of histone phosphorylation |
| histone-serine phosphorylation |
| regulation of histone phosphorylation |
| positive regulation of CREB transcription factor activity |
| histone phosphorylation |
| positive regulation of histone acetylation |
| positive regulation of peptidyl-lysine acetylation |
| positive regulation of protein acetylation |
| regulation of histone acetylation |
| regulation of peptidyl-lysine acetylation |
| regulation of protein acetylation |
| positive regulation of histone modification |
| interleukin-1-mediated signaling pathway |
| positive regulation of chromatin organization |
| regulation of histone modification |
| positive regulation of NF-kappaB transcription factor activity |
| peptidyl-serine phosphorylation |
| cellular response to interleukin-1 |
| positive regulation of chromosome organization |
| regulation of chromatin organization |
| peptidyl-serine modification |
| response to interleukin-1 |
| magnesium ion binding |
| positive regulation of DNA-binding transcription factor activity |
| negative regulation of cytokine production |
| regulation of chromosome organization |
| protein serine/threonine kinase activity |
| histone modification |
| covalent chromatin modification |
| regulation of DNA-binding transcription factor activity |
| inflammatory response |
| positive regulation of organelle organization |
| cytokine-mediated signaling pathway |
| regulation of cytokine production |
| chromatin organization |
| peptidyl-amino acid modification |
| protein phosphorylation |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| chromosome organization |
| response to cytokine |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| phosphorylation |
| regulation of organelle organization |
| defense response |
| regulation of protein phosphorylation |
| ATP binding |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7138
- Expression level (log2 read counts): 5.23
Expression Distribution
RPS6KA4 Expression in NALM6 Cells: 5.23
