RRAS

Entrez Summary: The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015].
UniProt Summary: Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). {ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:18270267}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

face morphogenesis
head morphogenesis
body morphogenesis
face development
GDP binding
positive regulation of angiogenesis
positive regulation of vasculature development
regulation of protein kinase B signaling
Ras protein signal transduction
negative regulation of cell migration
protein-containing complex binding
negative regulation of cell motility
regulation of angiogenesis
regulation of ERK1 and ERK2 cascade
negative regulation of cellular component movement
small GTPase mediated signal transduction
regulation of vasculature development
negative regulation of locomotion
GTPase activity
leukocyte differentiation
GTP binding
focal adhesion
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
regulation of MAPK cascade
head development
regulation of cell migration
regulation of cell motility
regulation of locomotion
regulation of cellular component movement
regulation of anatomical structure morphogenesis
positive regulation of developmental process
regulation of protein phosphorylation
regulation of phosphorylation
intracellular signal transduction
positive regulation of multicellular organismal process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of intracellular signal transduction