RRN3 [The Human Chemical-Genetic Interaction Map Project]

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======= RRN3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RRN3
  * **<color #00a2e8>Official Name</color>**: RRN3 homolog, RNA polymerase I transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54700|54700]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYV6|Q9NYV6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RRN3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RRN3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605121|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11265758, ECO:0000269|PubMed:15805466}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRN3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase I general transcription initiation factor activity|
|RNA polymerase I core binding|
|nucleolus organization|
|RNA polymerase I CORE element sequence-specific DNA binding|
|RNA polymerase I preinitiation complex assembly|
|cytoplasm organization|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|transcription preinitiation complex assembly|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|negative regulation of signal transduction by p53 class mediator|
|regulation of DNA-templated transcription, initiation|
|transcription initiation from RNA polymerase I promoter|
|transcription by RNA polymerase I|
|negative regulation of intrinsic apoptotic signaling pathway|
|nucleus organization|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of signal transduction by p53 class mediator|
|homeostasis of number of cells|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|negative regulation of apoptotic signaling pathway|
|protein-DNA complex subunit organization|
|positive regulation of neuron projection development|
|ribosome biogenesis|
|positive regulation of neuron differentiation|
|in utero embryonic development|
|positive regulation of cell projection organization|
|regulation of apoptotic signaling pathway|
|ribonucleoprotein complex biogenesis|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|negative regulation of intracellular signal transduction|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell population proliferation|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|cellular protein-containing complex assembly|
|nucleolus|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|embryo development|
|negative regulation of cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.76|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.72|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.72|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.76|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.76|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.79|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.9|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.98|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.99|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.581|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.568|
|[[:human genes:o:orc6|ORC6]]|0.553|
|[[:human genes:c:cdc73|CDC73]]|0.547|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.542|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.533|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.533|
|[[:human genes:t:tceb3c|TCEB3C]]|0.532|
|[[:human genes:z:znf106|ZNF106]]|0.531|
|[[:human genes:t:ticrr|TICRR]]|0.527|
|[[:human genes:p:psma6|PSMA6]]|0.517|
|[[:human genes:r:rrp15|RRP15]]|0.514|
|[[:human genes:p:psmb4|PSMB4]]|0.512|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.511|
|[[:human genes:s:supt5h|SUPT5H]]|0.509|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.507|
|[[:human genes:s:snrpa1|SNRPA1]]|0.507|
|[[:human genes:s:ssh2|SSH2]]|0.5|
|[[:human genes:d:dtl|DTL]]|0.492|
|[[:human genes:e:exosc3|EXOSC3]]|0.492|
|[[:human genes:c:chd4|CHD4]]|0.488|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.488|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.487|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.487|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.486|
|[[:human genes:p:psmb2|PSMB2]]|0.486|
|[[:human genes:r:rpl35|RPL35]]|0.486|
|[[:human genes:v:vasn|VASN]]|0.485|
|[[:human genes:c:c14orf93|C14orf93]]|0.484|
|[[:human genes:o:orc1|ORC1]]|0.483|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.483|
|[[:human genes:m:myo1h|MYO1H]]|0.48|
|[[:human genes:t:tfip11|TFIP11]]|0.48|
|[[:human genes:c:col2a1|COL2A1]]|0.48|
|[[:human genes:r:rps14|RPS14]]|0.48|
|[[:human genes:c:cgb2|CGB2]]|0.479|
|[[:human genes:p:psmd3|PSMD3]]|0.474|
|[[:human genes:a:ankle1|ANKLE1]]|0.472|
|[[:human genes:p:psmd6|PSMD6]]|0.472|
|[[:human genes:w:wdr87|WDR87]]|0.472|
|[[:human genes:a:acsf2|ACSF2]]|0.471|
|[[:human genes:p:psmc1|PSMC1]]|0.469|
|[[:human genes:z:zfand5|ZFAND5]]|0.467|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.467|
|[[:human genes:r:rbm39|RBM39]]|0.465|
|[[:human genes:c:cbwd3|CBWD3]]|0.465|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.465|
|[[:human genes:d:ddtl|DDTL]]|0.464|
|[[:human genes:p:psmd1|PSMD1]]|0.462|
|[[:human genes:p:psmc6|PSMC6]]|0.462|
|[[:human genes:d:dock6|DOCK6]]|0.462|
|[[:human genes:p:psma1|PSMA1]]|0.46|
|[[:human genes:c:chmp2a|CHMP2A]]|0.46|
|[[:human genes:p:pola2|POLA2]]|0.459|
|[[:human genes:p:psmc5|PSMC5]]|0.459|
|[[:human genes:r:rfxank|RFXANK]]|0.459|
|[[:human genes:t:twistnb|TWISTNB]]|0.459|
|[[:human genes:c:cdc45|CDC45]]|0.458|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.458|
|[[:human genes:s:sec13|SEC13]]|0.457|
|[[:human genes:l:lrr1|LRR1]]|0.456|
|[[:human genes:n:npipb5|NPIPB5]]|0.454|
|[[:human genes:m:mt1e|MT1E]]|0.454|
|[[:human genes:s:slc4a1|SLC4A1]]|0.454|
|[[:human genes:r:rps2|RPS2]]|0.453|
|[[:human genes:r:rad51|RAD51]]|0.452|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.452|
|[[:human genes:i:ik|IK]]|0.451|
|[[:human genes:p:psma7|PSMA7]]|0.45|
|[[:human genes:s:stil|STIL]]|0.45|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.449|
|[[:human genes:c:cope|COPE]]|0.448|
|[[:human genes:c:cbwd5|CBWD5]]|0.448|
|[[:human genes:s:syt9|SYT9]]|0.448|
|[[:human genes:s:smg1|SMG1]]|0.448|
|[[:human genes:p:polr2j3|POLR2J3]]|0.446|
|[[:human genes:c:copg1|COPG1]]|0.446|
|[[:human genes:t:tspy8|TSPY8]]|0.446|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.445|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.443|
|[[:human genes:p:psmd11|PSMD11]]|0.442|
|[[:human genes:p:psap|PSAP]]|0.441|
|[[:human genes:p:psmd7|PSMD7]]|0.441|
|[[:human genes:c:ccna2|CCNA2]]|0.44|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.44|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.439|
|[[:human genes:w:wdr75|WDR75]]|0.438|
|[[:human genes:m:msh5|MSH5]]|0.437|
|[[:human genes:z:znf219|ZNF219]]|0.437|
|[[:human genes:n:nup43|NUP43]]|0.437|
|[[:human genes:t:trim52|TRIM52]]|0.437|
|[[:human genes:r:rps7|RPS7]]|0.436|
|[[:human genes:n:narfl|NARFL]]|0.435|
|[[:human genes:k:kctd17|KCTD17]]|0.435|
|[[:human genes:p:psmb3|PSMB3]]|0.435|
|[[:human genes:s:s1pr4|S1PR4]]|0.434|
|[[:human genes:p:polr2d|POLR2D]]|0.432|
|[[:human genes:c:ccdc94|CCDC94]]|0.431|
|[[:human genes:a:ankle2|ANKLE2]]|0.431|
|[[:human genes:r:rbbp5|RBBP5]]|0.43|
|[[:human genes:g:golga6a|GOLGA6A]]|0.43|
|[[:human genes:w:wdr43|WDR43]]|0.429|
|[[:human genes:n:nbpf10|NBPF10]]|0.429|
|[[:human genes:r:rpl34|RPL34]]|0.429|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.428|
|[[:human genes:n:nop16|NOP16]]|0.428|
|[[:human genes:c:cdt1|CDT1]]|0.428|
|[[:human genes:n:nupl1|NUPL1]]|0.427|
|[[:human genes:m:myo18a|MYO18A]]|0.427|
|[[:human genes:t:tpx2|TPX2]]|0.427|
|[[:human genes:r:rps28|RPS28]]|0.427|
|[[:human genes:z:znf655|ZNF655]]|0.426|
|[[:human genes:p:paf1|PAF1]]|0.426|
|[[:human genes:z:znf675|ZNF675]]|0.426|
|[[:human genes:f:fam160a1|FAM160A1]]|0.426|
|[[:human genes:t:tspy1|TSPY1]]|0.426|
|[[:human genes:r:rangap1|RANGAP1]]|0.426|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.426|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.426|
|[[:human genes:p:polr2a|POLR2A]]|0.425|
|[[:human genes:i:igfn1|IGFN1]]|0.425|
|[[:human genes:a:aatf|AATF]]|0.424|
|[[:human genes:p:psmd2|PSMD2]]|0.423|
|[[:human genes:u:upf1|UPF1]]|0.423|
|[[:human genes:n:nup54|NUP54]]|0.423|
|[[:human genes:c:cbwd6|CBWD6]]|0.423|
|[[:human genes:r:rad21|RAD21]]|0.422|
|[[:human genes:s:sap30bp|SAP30BP]]|0.421|
|[[:human genes:r:rpl30|RPL30]]|0.421|
|[[:human genes:t:taf15|TAF15]]|0.42|
|[[:human genes:f:fam231c|FAM231C]]|0.419|
|[[:human genes:e:egr2|EGR2]]|0.419|
|[[:human genes:f:fam231a|FAM231A]]|0.419|
|[[:human genes:d:dhx38|DHX38]]|0.418|
|[[:human genes:p:psmd8|PSMD8]]|0.418|
|[[:human genes:c:cdca3|CDCA3]]|0.418|
|[[:human genes:s:sel1l|SEL1L]]|0.418|
|[[:human genes:c:cdc6|CDC6]]|0.418|
|[[:human genes:a:akirin2|AKIRIN2]]|0.416|
|[[:human genes:a:ahctf1|AHCTF1]]|0.416|
|[[:human genes:c:ctr9|CTR9]]|0.416|
|[[:human genes:x:xylt2|XYLT2]]|0.416|
|[[:human genes:r:rpsa|RPSA]]|0.416|
|[[:human genes:m:mylk3|MYLK3]]|0.415|
|[[:human genes:a:atp13a1|ATP13A1]]|0.414|
|[[:human genes:p:polr1a|POLR1A]]|0.414|
|[[:human genes:c:copb1|COPB1]]|0.413|
|[[:human genes:r:rrp7a|RRP7A]]|0.412|
|[[:human genes:s:smg7|SMG7]]|0.412|
|[[:human genes:p:pole|POLE]]|0.412|
|[[:human genes:p:pold1|POLD1]]|0.411|
|[[:human genes:r:rpl9|RPL9]]|0.411|
|[[:human genes:a:abhd8|ABHD8]]|0.41|
|[[:human genes:e:elmod3|ELMOD3]]|0.408|
|[[:human genes:s:supt6h|SUPT6H]]|0.408|
|[[:human genes:s:snip1|SNIP1]]|0.408|
|[[:human genes:d:disp2|DISP2]]|0.407|
|[[:human genes:a:aamp|AAMP]]|0.406|
|[[:human genes:v:vps28|VPS28]]|0.406|
|[[:human genes:s:sf3a3|SF3A3]]|0.406|
|[[:human genes:a:aqr|AQR]]|0.405|
|[[:human genes:s:srfbp1|SRFBP1]]|0.405|
|[[:human genes:u:uspl1|USPL1]]|0.405|
|[[:human genes:p:ppm1d|PPM1D]]|0.404|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.404|
|[[:human genes:n:npipb8|NPIPB8]]|0.404|
|[[:human genes:p:psmd14|PSMD14]]|0.404|
|[[:human genes:c:chmp4b|CHMP4B]]|0.403|
|[[:human genes:m:med17|MED17]]|0.403|
|[[:human genes:c:cactin|CACTIN]]|0.402|
|[[:human genes:s:slc38a7|SLC38A7]]|0.402|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.402|
|[[:human genes:k:kpnb1|KPNB1]]|0.402|
|[[:human genes:s:snrnp70|SNRNP70]]|0.401|
|[[:human genes:n:nup160|NUP160]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 612/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|21/28|
|blood|26/28|
|bone|22/26|
|breast|27/33|
|central nervous system|43/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|15/16|
|kidney|16/21|
|liver|19/20|
|lung|58/75|
|lymphocyte|15/16|
|ovary|23/26|
|pancreas|18/24|
|peripheral nervous system|10/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|24/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1131
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RRN3 Expression in NALM6 Cells: 7.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>