RRN3

Gene Information

Official Symbol: RRN3
Official Name: RRN3 homolog, RNA polymerase I transcription factor
Aliases and Previous Symbols: N/A
Entrez ID: 54700
UniProt: Q9NYV6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11265758, ECO:0000269|PubMed:15805466}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Monensin 0.3μM R08 exp507	-1.76
Aphidicolin 0.4μM R08 exp440	-1.72
2-Methoxyestradiol 0.55μM R07 exp310	1.72
IU1-C 25μM R04 exp183	1.76
Vincristine 0.0005μM R04 exp190	1.76
Chloramphenicol 2μM R00 exp12	1.79
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.9
CCCP 1μM R00 exp11	1.98
Wiskostatin 3μM R07 exp422	1.99
GSK-J4 1μM R07 exp362	2.1

Gene	Correlation
TBC1D3H	0.581
TBC1D3G	0.568
ORC6	0.553
CDC73	0.547
TCEB3CL	0.542
TBC1D3	0.533
TBC1D3C	0.533
TCEB3C	0.532
ZNF106	0.531
TICRR	0.527
PSMA6	0.517
RRP15	0.514
PSMB4	0.512
TCEB3CL2	0.511
SUPT5H	0.509
TBC1D3F	0.507
SNRPA1	0.507
SSH2	0.5
DTL	0.492
EXOSC3	0.492
CHD4	0.488
TBC1D3I	0.488
TBC1D3K	0.487
TBC1D3E	0.487
TBC1D3L	0.486
PSMB2	0.486
RPL35	0.486
VASN	0.485
C14orf93	0.484
ORC1	0.483
C1QTNF9B	0.483
MYO1H	0.48
TFIP11	0.48
COL2A1	0.48
RPS14	0.48
CGB2	0.479
PSMD3	0.474
ANKLE1	0.472
PSMD6	0.472
WDR87	0.472
ACSF2	0.471
PSMC1	0.469
ZFAND5	0.467
ARHGEF35	0.467
RBM39	0.465
CBWD3	0.465
EBNA1BP2	0.465
DDTL	0.464
PSMD1	0.462
PSMC6	0.462
DOCK6	0.462
PSMA1	0.46
CHMP2A	0.46
POLA2	0.459
PSMC5	0.459
RFXANK	0.459
TWISTNB	0.459
CDC45	0.458
DNTTIP2	0.458
SEC13	0.457
LRR1	0.456
NPIPB5	0.454
MT1E	0.454
SLC4A1	0.454
RPS2	0.453
RAD51	0.452
HGC6.3	0.452
IK	0.451
PSMA7	0.45
STIL	0.45
PLA2G4F	0.449
COPE	0.448
CBWD5	0.448
SYT9	0.448
SMG1	0.448
POLR2J3	0.446
COPG1	0.446
TSPY8	0.446
GOLGA6L3	0.445
HIST2H2BF	0.443
PSMD11	0.442
PSAP	0.441
PSMD7	0.441
CCNA2	0.44
PDE4DIP	0.44
RPS19BP1	0.439
WDR75	0.438
MSH5	0.437
ZNF219	0.437
NUP43	0.437
TRIM52	0.437
RPS7	0.436
NARFL	0.435
KCTD17	0.435
PSMB3	0.435
S1PR4	0.434
POLR2D	0.432
CCDC94	0.431
ANKLE2	0.431
RBBP5	0.43
GOLGA6A	0.43
WDR43	0.429
NBPF10	0.429
RPL34	0.429
ATP6V0C	0.428
NOP16	0.428
CDT1	0.428
NUPL1	0.427
MYO18A	0.427
TPX2	0.427
RPS28	0.427
ZNF655	0.426
PAF1	0.426
ZNF675	0.426
FAM160A1	0.426
TSPY1	0.426
RANGAP1	0.426
HIST2H3C	0.426
HIST2H3A	0.426
POLR2A	0.425
IGFN1	0.425
AATF	0.424
PSMD2	0.423
UPF1	0.423
NUP54	0.423
CBWD6	0.423
RAD21	0.422
SAP30BP	0.421
RPL30	0.421
TAF15	0.42
FAM231C	0.419
EGR2	0.419
FAM231A	0.419
DHX38	0.418
PSMD8	0.418
CDCA3	0.418
SEL1L	0.418
CDC6	0.418
AKIRIN2	0.416
AHCTF1	0.416
CTR9	0.416
XYLT2	0.416
RPSA	0.416
MYLK3	0.415
ATP13A1	0.414
POLR1A	0.414
COPB1	0.413
RRP7A	0.412
SMG7	0.412
POLE	0.412
POLD1	0.411
RPL9	0.411
ABHD8	0.41
ELMOD3	0.408
SUPT6H	0.408
SNIP1	0.408
DISP2	0.407
AAMP	0.406
VPS28	0.406
SF3A3	0.406
AQR	0.405
SRFBP1	0.405
USPL1	0.405
PPM1D	0.404
ATP6V1C1	0.404
NPIPB8	0.404
PSMD14	0.404
CHMP4B	0.403
MED17	0.403
CACTIN	0.402
SLC38A7	0.402
RPL7L1	0.402
KPNB1	0.402
SNRNP70	0.401
NUP160	0.401

Global Fraction of Cell Lines Where Essential: 612/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	21/28
blood	26/28
bone	22/26
breast	27/33
central nervous system	43/56
cervix	4/4
colorectal	14/17
esophagus	10/13
fibroblast	0/1
gastric	15/16
kidney	16/21
liver	19/20
lung	58/75
lymphocyte	15/16
ovary	23/26
pancreas	18/24
peripheral nervous system	10/16
plasma cell	9/15
prostate	1/1
skin	21/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	16/22
urinary tract	24/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 1131
Expression level (log2 read counts): 7.07

Expression Distribution

RNA polymerase I general transcription initiation factor activity
RNA polymerase I core binding
nucleolus organization
RNA polymerase I CORE element sequence-specific DNA binding
RNA polymerase I preinitiation complex assembly
cytoplasm organization
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
transcription preinitiation complex assembly
regulation of intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of signal transduction by p53 class mediator
regulation of DNA-templated transcription, initiation
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
negative regulation of intrinsic apoptotic signaling pathway
nucleus organization
regulation of intrinsic apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
homeostasis of number of cells
protein-DNA complex assembly
DNA-templated transcription, initiation
negative regulation of apoptotic signaling pathway
protein-DNA complex subunit organization
positive regulation of neuron projection development
ribosome biogenesis
positive regulation of neuron differentiation
in utero embryonic development
positive regulation of cell projection organization
regulation of apoptotic signaling pathway
ribonucleoprotein complex biogenesis
positive regulation of neurogenesis
regulation of neuron projection development
negative regulation of intracellular signal transduction
positive regulation of nervous system development
positive regulation of cell development
cell population proliferation
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription
embryo development ending in birth or egg hatching
RNA biosynthetic process