RRP1B [The Human Chemical-Genetic Interaction Map Project]

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======= RRP1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RRP1B
  * **<color #00a2e8>Official Name</color>**: ribosomal RNA processing 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23076|23076]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14684|Q14684]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RRP1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RRP1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610654|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nop52|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|granular component|
|euchromatin|
|preribosome, small subunit precursor|
|positive regulation by host of viral transcription|
|preribosome, large subunit precursor|
|heterochromatin|
|cellular response to virus|
|positive regulation of viral transcription|
|negative regulation of GTPase activity|
|regulation of viral transcription|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|negative regulation of phosphatase activity|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|negative regulation of dephosphorylation|
|regulation of RNA splicing|
|modification of morphology or physiology of other organism|
|regulation of phosphatase activity|
|regulation of viral process|
|regulation of dephosphorylation|
|rRNA processing|
|regulation of symbiosis, encompassing mutualism through parasitism|
|rRNA metabolic process|
|response to virus|
|transcription coactivator activity|
|ribosome biogenesis|
|ncRNA processing|
|RNA splicing|
|negative regulation of hydrolase activity|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|regulation of GTPase activity|
|positive regulation of multi-organism process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|mRNA metabolic process|
|positive regulation of cell death|
|regulation of multi-organism process|
|symbiotic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|nucleolus|
|RNA processing|
|apoptotic process|
|programmed cell death|
|cell death|
|negative regulation of molecular function|
|positive regulation of transcription by RNA polymerase II|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|RNA binding|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.74|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.82|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.17|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5913
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RRP1B Expression in NALM6 Cells: 7.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>