RRP1B

Entrez Summary: N/A
UniProt Summary: Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

granular component
euchromatin
preribosome, small subunit precursor
positive regulation by host of viral transcription
preribosome, large subunit precursor
heterochromatin
cellular response to virus
positive regulation of viral transcription
negative regulation of GTPase activity
regulation of viral transcription
modification by host of symbiont morphology or physiology
interaction with symbiont
negative regulation of phosphatase activity
positive regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction
negative regulation of dephosphorylation
regulation of RNA splicing
modification of morphology or physiology of other organism
regulation of phosphatase activity
regulation of viral process
regulation of dephosphorylation
rRNA processing
regulation of symbiosis, encompassing mutualism through parasitism
rRNA metabolic process
response to virus
transcription coactivator activity
ribosome biogenesis
ncRNA processing
RNA splicing
negative regulation of hydrolase activity
ribonucleoprotein complex biogenesis
ncRNA metabolic process
mRNA processing
regulation of GTPase activity
positive regulation of multi-organism process
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
positive regulation of apoptotic process
positive regulation of programmed cell death
mRNA metabolic process