RRP8

Entrez Summary: N/A
UniProt Summary: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BI-6727 0.0125μM R03 exp97	-1.75
UM0129480 7μM R02 exp85	2.12

Methyltransf 8
Methyltransf 11

rDNA heterochromatin
regulation of transcription by glucose
chromatin silencing complex
S-adenosylmethionine-dependent methyltransferase activity
chromatin silencing at rDNA
cellular response to glucose starvation
intrinsic apoptotic signaling pathway by p53 class mediator
chromatin silencing
chromatin organization involved in negative regulation of transcription
methylated histone binding
chromatin organization involved in regulation of transcription
positive regulation of cell cycle arrest
negative regulation of gene expression, epigenetic
regulation of cell cycle arrest
signal transduction by p53 class mediator
intrinsic apoptotic signaling pathway
cellular response to starvation
gene silencing
response to starvation
rRNA processing
rRNA metabolic process
cellular response to nutrient levels
regulation of gene expression, epigenetic
cellular response to extracellular stimulus
apoptotic signaling pathway
positive regulation of cell cycle process
ribosome biogenesis
methylation
cellular response to external stimulus
positive regulation of cell cycle
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
response to nutrient levels
response to extracellular stimulus
chromatin organization
regulation of cell cycle process
nucleolus
RNA processing
apoptotic process