RTKN

Entrez Summary: N/A
UniProt Summary: Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PH
HR1

protein localization to mitotic actomyosin contractile ring
protein localization to actomyosin contractile ring
septin ring organization
protein localization to cell division site
protein localization to actin cytoskeleton
septin cytoskeleton organization
actomyosin contractile ring
protein localization to cell cortex
assembly of actomyosin apparatus involved in cytokinesis
actomyosin contractile ring assembly
actomyosin contractile ring organization
GTPase inhibitor activity
GTP-Rho binding
cytokinetic process
protein localization to cytoskeleton
cortical actin cytoskeleton organization
negative regulation of GTPase activity
cortical cytoskeleton organization
mitotic cytokinesis
Rho protein signal transduction
cytoskeleton-dependent cytokinesis
cytokinesis
actomyosin structure organization
protein localization to cell periphery
Ras protein signal transduction
small GTPase mediated signal transduction
GTP binding
cellular component
negative regulation of hydrolase activity
regulation of GTPase activity
cell division
actin cytoskeleton organization
actin filament-based process
mitotic cell cycle process
mitotic cell cycle
protein localization to organelle
negative regulation of catalytic activity
apoptotic process
cell cycle process
programmed cell death