RUFY1

Entrez Summary: This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
UniProt Summary: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. {ECO:0000269|PubMed:14617813}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rifampicin 30μM R08 exp430	-1.85
FK-506 5μM R07 exp358	1.71

FYVE
RUN

SH2 domain binding
phosphatidylinositol biosynthetic process
SH3 domain binding
early endosome membrane
lipid binding
phosphatidylinositol metabolic process
regulation of endocytosis
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
endosome
glycerophospholipid metabolic process
small GTPase mediated signal transduction
phospholipid metabolic process
glycerolipid metabolic process
nuclear speck
organophosphate biosynthetic process
regulation of vesicle-mediated transport
endocytosis
lipid biosynthetic process
import into cell
intracellular membrane-bounded organelle
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
protein transport
peptide transport
amide transport
establishment of protein localization
intracellular signal transduction
nitrogen compound transport
regulation of transport
vesicle-mediated transport