RUVBL1 [The Human Chemical-Genetic Interaction Map Project]

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======= RUVBL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RUVBL1
  * **<color #00a2e8>Official Name</color>**: RuvB like AAA ATPase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8607|8607]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y265|Q9Y265]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RUVBL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RUVBL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603449|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May be able to bind plasminogen at cell surface and enhance plasminogen activation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA|
|TIP49|
|RuvB N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|R2TP complex|
|box C/D snoRNP assembly|
|TFIID-class transcription factor complex binding|
|small nucleolar ribonucleoprotein complex assembly|
|Swr1 complex|
|positive regulation of telomerase RNA localization to Cajal body|
|Ino80 complex|
|histone H2A acetylation|
|regulation of telomerase RNA localization to Cajal body|
|NuA4 histone acetyltransferase complex|
|TBP-class protein binding|
|beta-catenin-TCF complex assembly|
|MLL1 complex|
|CENP-A containing nucleosome assembly|
|CENP-A containing chromatin organization|
|chromatin remodeling at centromere|
|ADP binding|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|histone exchange|
|histone H4 acetylation|
|DNA helicase activity|
|ATP-dependent chromatin remodeling|
|ATPase binding|
|nuclear matrix|
|DNA duplex unwinding|
|histone acetylation|
|nucleosome assembly|
|internal peptidyl-lysine acetylation|
|DNA geometric change|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|chromatin assembly|
|protein acetylation|
|positive regulation of canonical Wnt signaling pathway|
|ribonucleoprotein complex|
|chromatin assembly or disassembly|
|nucleosome organization|
|microtubule organizing center|
|chromatin remodeling|
|positive regulation of Wnt signaling pathway|
|DNA packaging|
|protein acylation|
|protein-DNA complex assembly|
|DNA recombination|
|ribonucleoprotein complex assembly|
|ATPase activity|
|protein-DNA complex subunit organization|
|ribonucleoprotein complex subunit organization|
|regulation of canonical Wnt signaling pathway|
|protein deubiquitination|
|transcription coactivator activity|
|DNA conformation change|
|protein modification by small protein removal|
|cadherin binding|
|peptidyl-lysine modification|
|regulation of Wnt signaling pathway|
|histone modification|
|covalent chromatin modification|
|ribonucleoprotein complex biogenesis|
|cell division|
|DNA repair|
|spermatogenesis|
|male gamete generation|
|regulation of growth|
|gamete generation|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|chromosome organization|
|proteolysis|
|cell cycle|
|reproductive process|
|reproduction|
|ATP binding|
|protein-containing complex assembly|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.94|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.85|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.73|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-2.17|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2.1|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.88|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.8|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.75|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.74|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.72|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.75|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.76|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.76|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.85|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.93|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.94|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.96|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.13|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.15|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.51|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.505|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 23
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RUVBL1 Expression in NALM6 Cells: 6.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>