RUVBL1

• Official Symbol: RUVBL1
• Official Name: RuvB like AAA ATPase 1
• Aliases and Previous Symbols: N/A
• Entrez ID: 8607
• UniProt: Q9Y265
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: N/A
• UniProt Summary: Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May be able to bind plasminogen at cell surface and enhance plasminogen activation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 23
• Expression level (log2 read counts): 6.54

Expression Distribution

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RUVBL1 Expression in NALM6 Cells: 6.54