RUVBL2 [The Human Chemical-Genetic Interaction Map Project]

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======= RUVBL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RUVBL2
  * **<color #00a2e8>Official Name</color>**: RuvB like AAA ATPase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10856|10856]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y230|Q9Y230]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RUVBL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RUVBL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604788|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes. {ECO:0000269|PubMed:25652260}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIP49|
|DnaB C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of estrogen receptor binding|
|regulation of estrogen receptor binding|
|gene looping|
|dsDNA loop formation|
|transcriptional activation by promoter-enhancer looping|
|R2TP complex|
|establishment of protein localization to chromatin|
|box C/D snoRNP assembly|
|small nucleolar ribonucleoprotein complex assembly|
|TFIID-class transcription factor complex binding|
|Swr1 complex|
|negative regulation of receptor binding|
|positive regulation of telomerase RNA localization to Cajal body|
|establishment of protein localization to chromosome|
|Ino80 complex|
|histone H2A acetylation|
|regulation of telomerase RNA localization to Cajal body|
|NuA4 histone acetyltransferase complex|
|TBP-class protein binding|
|regulation of receptor binding|
|protein localization to chromatin|
|positive regulation of histone acetylation|
|MLL1 complex|
|nuclear euchromatin|
|positive regulation of peptidyl-lysine acetylation|
|RNA polymerase II core promoter sequence-specific DNA binding|
|cellular response to estradiol stimulus|
|ADP binding|
|positive regulation of protein acetylation|
|histone H4 acetylation|
|regulation of histone acetylation|
|DNA helicase activity|
|regulation of peptidyl-lysine acetylation|
|protein localization to chromosome|
|regulation of protein acetylation|
|chromatin DNA binding|
|ATPase binding|
|cellular response to UV|
|beta-catenin binding|
|intracellular|
|positive regulation of histone modification|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|negative regulation of protein binding|
|positive regulation of chromatin organization|
|nuclear matrix|
|DNA duplex unwinding|
|cellular response to light stimulus|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|DNA geometric change|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|unfolded protein binding|
|response to estradiol|
|response to UV|
|protein acetylation|
|regulation of histone modification|
|ribonucleoprotein complex|
|chromatin remodeling|
|negative regulation of binding|
|negative regulation of canonical Wnt signaling pathway|
|cellular response to radiation|
|positive regulation of chromosome organization|
|protein acylation|
|regulation of chromatin organization|
|negative regulation of Wnt signaling pathway|
|regulation of protein binding|
|DNA recombination|
|protein folding|
|ribonucleoprotein complex assembly|
|ATPase activity|
|transcription corepressor activity|
|ribonucleoprotein complex subunit organization|
|regulation of canonical Wnt signaling pathway|
|DNA conformation change|
|response to light stimulus|
|peptidyl-lysine modification|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of chromosome organization|
|regulation of Wnt signaling pathway|
|histone modification|
|covalent chromatin modification|
|regulation of binding|
|establishment of protein localization to organelle|
|response to radiation|
|ribonucleoprotein complex biogenesis|
|centrosome|
|DNA repair|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|regulation of growth|
|chromatin organization|
|protein localization to organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|response to lipid|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|response to hormone|
|response to organic cyclic compound|
|cellular response to oxygen-containing compound|
|chromosome organization|
|identical protein binding|
|negative regulation of molecular function|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.59|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.88|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.81|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.81|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.72|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.74|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.85|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.98|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hist1h2ai|HIST1H2AI]]|0.583|
|[[:human genes:b:btbd18|BTBD18]]|0.558|
|[[:human genes:p:pear1|PEAR1]]|0.539|
|[[:human genes:p:pmel|PMEL]]|0.533|
|[[:human genes:a:arfgef1|ARFGEF1]]|0.532|
|[[:human genes:r:rprml|RPRML]]|0.526|
|[[:human genes:p:ppp1r14a|PPP1R14A]]|0.509|
|[[:human genes:t:tpm2|TPM2]]|0.501|
|[[:human genes:t:tbata|TBATA]]|0.501|
|[[:human genes:p:polr2g|POLR2G]]|0.498|
|[[:human genes:c:c9orf114|C9orf114]]|0.494|
|[[:human genes:d:dhx15|DHX15]]|0.493|
|[[:human genes:n:ncbp2|NCBP2]]|0.49|
|[[:human genes:p:ppp6r3|PPP6R3]]|0.49|
|[[:human genes:c:copb2|COPB2]]|0.49|
|[[:human genes:p:pth2r|PTH2R]]|0.483|
|[[:human genes:l:lair1|LAIR1]]|0.483|
|[[:human genes:t:tspy1|TSPY1]]|0.483|
|[[:human genes:a:aim1|AIM1]]|0.482|
|[[:human genes:u:uqcrh|UQCRH]]|0.481|
|[[:human genes:r:rnf40|RNF40]]|0.479|
|[[:human genes:n:ndrg2|NDRG2]]|0.477|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.475|
|[[:human genes:l:loc100505679|LOC100505679]]|0.471|
|[[:human genes:n:ndrg4|NDRG4]]|0.469|
|[[:human genes:d:dennd1a|DENND1A]]|0.467|
|[[:human genes:r:rrp7a|RRP7A]]|0.465|
|[[:human genes:h:hsd3b7|HSD3B7]]|0.463|
|[[:human genes:p:pigs|PIGS]]|0.462|
|[[:human genes:s:slc45a2|SLC45A2]]|0.461|
|[[:human genes:t:tldc2|TLDC2]]|0.46|
|[[:human genes:c:c4orf32|C4orf32]]|0.459|
|[[:human genes:h:hist1h2bf|HIST1H2BF]]|0.459|
|[[:human genes:m:march4|MARCH4]]|0.458|
|[[:human genes:c:ccng2|CCNG2]]|0.458|
|[[:human genes:z:znf20|ZNF20]]|0.456|
|[[:human genes:a:actn4|ACTN4]]|0.454|
|[[:human genes:p:ppp2r5a|PPP2R5A]]|0.451|
|[[:human genes:s:sec13|SEC13]]|0.45|
|[[:human genes:m:mgat4d|MGAT4D]]|0.448|
|[[:human genes:m:mul1|MUL1]]|0.447|
|[[:human genes:v:vwc2|VWC2]]|0.446|
|[[:human genes:s:sptan1|SPTAN1]]|0.445|
|[[:human genes:o:or4f5|OR4F5]]|0.444|
|[[:human genes:d:dcd|DCD]]|0.444|
|[[:human genes:y:ythdf1|YTHDF1]]|0.443|
|[[:human genes:p:pry|PRY]]|0.441|
|[[:human genes:u:uchl1|UCHL1]]|0.441|
|[[:human genes:p:pry2|PRY2]]|0.44|
|[[:human genes:h:h3f3a|H3F3A]]|0.44|
|[[:human genes:z:zik1|ZIK1]]|0.439|
|[[:human genes:r:rev3l|REV3L]]|0.439|
|[[:human genes:p:ppp3ca|PPP3CA]]|0.438|
|[[:human genes:m:mtch2|MTCH2]]|0.438|
|[[:human genes:e:exosc8|EXOSC8]]|0.438|
|[[:human genes:t:tcf21|TCF21]]|0.437|
|[[:human genes:a:arl17a|ARL17A]]|0.437|
|[[:human genes:f:focad|FOCAD]]|0.436|
|[[:human genes:c:cd6|CD6]]|0.436|
|[[:human genes:r:rnf121|RNF121]]|0.435|
|[[:human genes:g:garem|GAREM]]|0.434|
|[[:human genes:v:vps16|VPS16]]|0.433|
|[[:human genes:e:etv3|ETV3]]|0.432|
|[[:human genes:a:adam15|ADAM15]]|0.432|
|[[:human genes:c:c13orf35|C13orf35]]|0.432|
|[[:human genes:m:med17|MED17]]|0.429|
|[[:human genes:g:gna15|GNA15]]|0.429|
|[[:human genes:k:kif24|KIF24]]|0.428|
|[[:human genes:e:esam|ESAM]]|0.428|
|[[:human genes:p:ppp1r16a|PPP1R16A]]|0.428|
|[[:human genes:p:prpf31|PRPF31]]|0.428|
|[[:human genes:z:zfat|ZFAT]]|0.427|
|[[:human genes:p:pwwp2a|PWWP2A]]|0.427|
|[[:human genes:t:tceb3c|TCEB3C]]|0.427|
|[[:human genes:c:cdk17|CDK17]]|0.427|
|[[:human genes:s:snrnp200|SNRNP200]]|0.426|
|[[:human genes:o:osbp|OSBP]]|0.425|
|[[:human genes:s:s1pr5|S1PR5]]|0.424|
|[[:human genes:n:npipa8|NPIPA8]]|0.423|
|[[:human genes:p:psmb2|PSMB2]]|0.423|
|[[:human genes:z:znf655|ZNF655]]|0.422|
|[[:human genes:l:ldlr|LDLR]]|0.422|
|[[:human genes:n:npipa7|NPIPA7]]|0.422|
|[[:human genes:g:gzmb|GZMB]]|0.422|
|[[:human genes:f:fam160b1|FAM160B1]]|0.421|
|[[:human genes:l:lrp4|LRP4]]|0.421|
|[[:human genes:s:selm|SELM]]|0.421|
|[[:human genes:t:tmem63c|TMEM63C]]|0.42|
|[[:human genes:s:supt6h|SUPT6H]]|0.419|
|[[:human genes:s:slc35f3|SLC35F3]]|0.419|
|[[:human genes:m:mmab|MMAB]]|0.419|
|[[:human genes:c:ccdc149|CCDC149]]|0.418|
|[[:human genes:a:ap2s1|AP2S1]]|0.417|
|[[:human genes:s:slc1a6|SLC1A6]]|0.417|
|[[:human genes:t:tnp2|TNP2]]|0.417|
|[[:human genes:t:tvp23c|TVP23C]]|0.416|
|[[:human genes:p:polr2j3|POLR2J3]]|0.416|
|[[:human genes:s:sult1b1|SULT1B1]]|0.416|
|[[:human genes:c:col6a6|COL6A6]]|0.415|
|[[:human genes:k:klf5|KLF5]]|0.414|
|[[:human genes:p:p3h3|P3H3]]|0.413|
|[[:human genes:s:senp7|SENP7]]|0.412|
|[[:human genes:t:tnfaip8l2|TNFAIP8L2]]|0.412|
|[[:human genes:m:mpped2|MPPED2]]|0.412|
|[[:human genes:m:mt3|MT3]]|0.412|
|[[:human genes:n:nup205|NUP205]]|0.411|
|[[:human genes:k:kpnb1|KPNB1]]|0.411|
|[[:human genes:l:lrrc56|LRRC56]]|0.411|
|[[:human genes:s:slc16a7|SLC16A7]]|0.411|
|[[:human genes:p:polr2j2|POLR2J2]]|0.411|
|[[:human genes:c:copb1|COPB1]]|0.41|
|[[:human genes:i:itm2c|ITM2C]]|0.41|
|[[:human genes:p:polr2a|POLR2A]]|0.41|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.41|
|[[:human genes:g:gprin2|GPRIN2]]|0.409|
|[[:human genes:c:ctrb1|CTRB1]]|0.409|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.409|
|[[:human genes:k:kir3dl3|KIR3DL3]]|0.408|
|[[:human genes:k:klrk1|KLRK1]]|0.408|
|[[:human genes:z:znf254|ZNF254]]|0.408|
|[[:human genes:w:wdr7|WDR7]]|0.408|
|[[:human genes:s:slc16a10|SLC16A10]]|0.407|
|[[:human genes:s:syngr1|SYNGR1]]|0.407|
|[[:human genes:m:myh7|MYH7]]|0.406|
|[[:human genes:c:ccin|CCIN]]|0.406|
|[[:human genes:c:c14orf132|C14orf132]]|0.406|
|[[:human genes:g:gnb1|GNB1]]|0.405|
|[[:human genes:r:rab5c|RAB5C]]|0.405|
|[[:human genes:g:gns|GNS]]|0.405|
|[[:human genes:u:usp29|USP29]]|0.404|
|[[:human genes:c:cabs1|CABS1]]|0.404|
|[[:human genes:c:c5orf54|C5orf54]]|0.404|
|[[:human genes:e:emcn|EMCN]]|0.403|
|[[:human genes:f:fcn2|FCN2]]|0.403|
|[[:human genes:m:mgam|MGAM]]|0.403|
|[[:human genes:p:prkacb|PRKACB]]|0.403|
|[[:human genes:m:ms4a10|MS4A10]]|0.403|
|[[:human genes:f:fbl|FBL]]|0.401|
|[[:human genes:g:glyatl3|GLYATL3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 725/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 86
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RUVBL2 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>