RUVBL2

Entrez Summary: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008].
UniProt Summary: Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes. {ECO:0000269|PubMed:25652260}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 725/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Expression Distribution

TIP49
DnaB C

negative regulation of estrogen receptor binding
regulation of estrogen receptor binding
gene looping
dsDNA loop formation
transcriptional activation by promoter-enhancer looping
R2TP complex
establishment of protein localization to chromatin
box C/D snoRNP assembly
small nucleolar ribonucleoprotein complex assembly
TFIID-class transcription factor complex binding
Swr1 complex
negative regulation of receptor binding
positive regulation of telomerase RNA localization to Cajal body
establishment of protein localization to chromosome
Ino80 complex
histone H2A acetylation
regulation of telomerase RNA localization to Cajal body
NuA4 histone acetyltransferase complex
TBP-class protein binding
regulation of receptor binding
protein localization to chromatin
positive regulation of histone acetylation
MLL1 complex
nuclear euchromatin
positive regulation of peptidyl-lysine acetylation
RNA polymerase II core promoter sequence-specific DNA binding
cellular response to estradiol stimulus
ADP binding
positive regulation of protein acetylation
histone H4 acetylation
regulation of histone acetylation
DNA helicase activity
regulation of peptidyl-lysine acetylation
protein localization to chromosome
regulation of protein acetylation
chromatin DNA binding
ATPase binding
cellular response to UV
beta-catenin binding
intracellular