PEAR1

Entrez Summary: N/A
UniProt Summary: When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

recognition of apoptotic cell
phagocytic cup
phosphatidylinositol 3-kinase signaling
protein kinase B signaling
apoptotic cell clearance
negative regulation of Notch signaling pathway
platelet aggregation
homotypic cell-cell adhesion
phosphatidylinositol-mediated signaling
inositol lipid-mediated signaling
regulation of Notch signaling pathway
phagocytosis, recognition
platelet activation
signaling receptor activity
cell recognition
blood coagulation
coagulation
hemostasis
phagocytosis
wound healing
regulation of body fluid levels
cell-cell adhesion
endocytosis
response to wounding
import into cell
cell adhesion
biological adhesion
cell activation
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
intracellular signal transduction
vesicle-mediated transport