S100A13

Entrez Summary: N/A
UniProt Summary: Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). {ECO:0000250, ECO:0000269|PubMed:12746488, ECO:0000269|PubMed:20863990}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

interleukin-1 alpha production
interleukin-1 alpha secretion
interleukin-1 secretion
RAGE receptor binding
interleukin-1 production
mast cell degranulation
mast cell activation involved in immune response
mast cell mediated immunity
mast cell granule
mast cell activation
fibroblast growth factor binding
response to electrical stimulus
lysosome localization
response to copper ion
cytokine secretion
copper ion binding
cytokine production
regulation of cell shape
lipid binding
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of I-kappaB kinase/NF-kappaB signaling
establishment of organelle localization
response to metal ion
regulation of cell morphogenesis
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
response to inorganic substance
organelle localization
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
perinuclear region of cytoplasm
regulated exocytosis
calcium ion binding
leukocyte mediated immunity