S100A6

Entrez Summary: N/A
UniProt Summary: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. {ECO:0000269|PubMed:22399290}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ion transmembrane transporter activity
S100 protein binding
tropomyosin binding
positive regulation of fibroblast proliferation
extrinsic component of cytoplasmic side of plasma membrane
calcium-dependent protein binding
regulation of fibroblast proliferation
ruffle
nuclear envelope
collagen-containing extracellular matrix
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
cell morphogenesis involved in differentiation
neuron projection development
perinuclear region of cytoplasm
calcium ion binding
cell morphogenesis
neuron development
cellular component morphogenesis
zinc ion binding
protein homodimerization activity
positive regulation of cell population proliferation
ion transmembrane transport
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
transmembrane transport
ion transport
generation of neurons
regulation of cell population proliferation
neurogenesis
cell development
extracellular region