S100A7 [The Human Chemical-Genetic Interaction Map Project]

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======= S100A7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: S100A7
  * **<color #00a2e8>Official Name</color>**: S100 calcium binding protein A7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6278|6278]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31151|P31151]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=S100A7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20S100A7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600353|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|S 100|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RAGE receptor binding|
|sequestering of metal ion|
|positive regulation of T cell chemotaxis|
|regulation of T cell chemotaxis|
|positive regulation of monocyte chemotaxis|
|positive regulation of lymphocyte chemotaxis|
|positive regulation of mononuclear cell migration|
|regulation of monocyte chemotaxis|
|positive regulation of granulocyte chemotaxis|
|regulation of lymphocyte chemotaxis|
|positive regulation of T cell migration|
|positive regulation of lymphocyte migration|
|regulation of granulocyte chemotaxis|
|regulation of T cell migration|
|regulation of mononuclear cell migration|
|regulation of lymphocyte migration|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|defense response to Gram-negative bacterium|
|positive regulation of leukocyte chemotaxis|
|azurophil granule lumen|
|antimicrobial humoral response|
|regulation of leukocyte chemotaxis|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|maintenance of location|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|keratinocyte differentiation|
|regulation of ERK1 and ERK2 cascade|
|response to lipopolysaccharide|
|epidermal cell differentiation|
|angiogenesis|
|response to molecule of bacterial origin|
|defense response to bacterium|
|humoral immune response|
|collagen-containing extracellular matrix|
|skin development|
|response to oxidative stress|
|blood vessel morphogenesis|
|epidermis development|
|focal adhesion|
|neutrophil degranulation|
|blood vessel development|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|vasculature development|
|myeloid leukocyte mediated immunity|
|cardiovascular system development|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|tube morphogenesis|
|epithelial cell differentiation|
|response to bacterium|
|regulated exocytosis|
|calcium ion binding|
|regulation of MAPK cascade|
|innate immune response|
|leukocyte mediated immunity|
|exocytosis|
|zinc ion binding|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|leukocyte activation|
|defense response to other organism|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|epithelium development|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of protein phosphorylation|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.476|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17732
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='S100A7 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>