S1PR2

Gene Information

Official Symbol: S1PR2
Official Name: sphingosine-1-phosphate receptor 2
Aliases and Previous Symbols: N/A
Entrez ID: 9294
UniProt: O95136
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016].
UniProt Summary: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4074
Expression level (log2 read counts): 3.9

Expression Distribution

positive regulation of establishment of endothelial barrier
positive regulation of endothelial cell development
sphingosine-1-phosphate receptor activity
sphingosine-1-phosphate receptor signaling pathway
negative regulation of excitatory postsynaptic potential
sphingolipid mediated signaling pathway
regulation of endothelial cell development
regulation of establishment of endothelial barrier
positive regulation of endothelial cell differentiation
filopodium assembly
negative regulation of nervous system process
positive regulation of peptidyl-threonine phosphorylation
regulation of endothelial cell differentiation
modulation of excitatory postsynaptic potential
regulation of peptidyl-threonine phosphorylation
positive regulation of epithelial cell differentiation
negative regulation of synaptic transmission
actin cytoskeleton reorganization
G protein-coupled receptor binding
integrin binding
regulation of nervous system process
regulation of epithelial cell differentiation
activation of MAPK activity
lipid binding
positive regulation of MAP kinase activity
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
regulation of membrane potential
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
plasma membrane bounded cell projection assembly
cell projection assembly
actin cytoskeleton organization
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of cell development
positive regulation of MAPK cascade
actin filament-based process
positive regulation of kinase activity