SAE1 [The Human Chemical-Genetic Interaction Map Project]

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======= SAE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAE1
  * **<color #00a2e8>Official Name</color>**: SUMO1 activating enzyme subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10055|10055]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBE0|Q9UBE0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613294|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ThiF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SUMO activating enzyme activity|
|SUMO activating enzyme complex|
|ubiquitin activating enzyme activity|
|small protein activating enzyme binding|
|ATP-dependent protein binding|
|positive regulation of protein targeting to mitochondrion|
|regulation of protein targeting to mitochondrion|
|enzyme activator activity|
|positive regulation of establishment of protein localization to mitochondrion|
|protein sumoylation|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|positive regulation of mitochondrion organization|
|positive regulation of intracellular protein transport|
|regulation of mitochondrion organization|
|protein C-terminus binding|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|peptidyl-lysine modification|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|protein heterodimerization activity|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|protein ubiquitination|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of protein localization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.22|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-2|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.99|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.99|
|[[:results:exp539|42°C R08 exp539]]|-1.93|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.91|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.85|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.83|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.82|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.8|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.75|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.73|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.7|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.7|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:uba2|UBA2]]|0.475|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 731/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|18/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 804
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAE1 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>