SAE1

Gene Information

Official Symbol: SAE1
Official Name: SUMO1 activating enzyme subunit 1
Aliases and Previous Symbols: N/A
Entrez ID: 10055
UniProt: Q9UBE0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
5-Fluorouracil 20μM R00 exp2	-2.22
GSK-LSD1 10μM R03 exp123	-2
MK2206 4μM R08 exp504	-1.99
WYE-354 6μM R02 exp90	-1.99
42°C R08 exp539	-1.93
Epothilone-B 0.0015μM R05 exp231	-1.91
Pterostilbene 16μM R02 exp78	-1.85
EPZ-5676 30μM R05 exp233	-1.83
Etoposide 1μM R00 exp19	-1.82
Mubritinib 0.2μM R02 exp65	-1.8
Pimelic-diphenylamide-106 5μM R00 exp28	-1.75
Pyrazinamide 100μM R08 exp516	-1.73
Bortezomib 0.005μM R00 exp6	-1.7
Brefeldin A 0.02μM R00 exp8	-1.7
Talazoparib 0.006μM R06 exp299	2.83

Global Fraction of Cell Lines Where Essential: 731/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	18/20
lung	75/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 804
Expression level (log2 read counts): 7.39

Expression Distribution

SUMO activating enzyme activity
SUMO activating enzyme complex
ubiquitin activating enzyme activity
small protein activating enzyme binding
ATP-dependent protein binding
positive regulation of protein targeting to mitochondrion
regulation of protein targeting to mitochondrion
enzyme activator activity
positive regulation of establishment of protein localization to mitochondrion
protein sumoylation
regulation of establishment of protein localization to mitochondrion
regulation of protein targeting
positive regulation of mitochondrion organization
positive regulation of intracellular protein transport
regulation of mitochondrion organization
protein C-terminus binding
positive regulation of intracellular transport
regulation of intracellular protein transport
peptidyl-lysine modification
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport
positive regulation of establishment of protein localization
protein heterodimerization activity
regulation of cellular protein localization
positive regulation of organelle organization
protein ubiquitination
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
protein modification by small protein conjugation
peptidyl-amino acid modification
regulation of cellular localization
protein modification by small protein conjugation or removal
positive regulation of transport
regulation of protein localization
positive regulation of cellular component organization
regulation of organelle organization
positive regulation of catalytic activity
positive regulation of molecular function