SALL1 [The Human Chemical-Genetic Interaction Map Project]

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======= SALL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SALL1
  * **<color #00a2e8>Official Name</color>**: spalt like transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6299|6299]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NSC2|Q9NSC2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SALL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SALL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602218|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor involved in organogenesis. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inductive cell-cell signaling|
|olfactory bulb mitral cell layer development|
|olfactory nerve development|
|ureteric bud invasion|
|metanephric renal vesicle formation|
|ureteric bud elongation|
|renal vesicle formation|
|mesenchymal to epithelial transition involved in metanephros morphogenesis|
|outer ear morphogenesis|
|metanephric renal vesicle morphogenesis|
|chromocenter|
|renal vesicle morphogenesis|
|renal vesicle development|
|olfactory bulb interneuron differentiation|
|mesenchymal to epithelial transition|
|cell differentiation involved in metanephros development|
|metanephric nephron morphogenesis|
|adrenal gland development|
|heterochromatin|
|metanephros morphogenesis|
|developmental induction|
|epithelial cell differentiation involved in kidney development|
|metanephric nephron development|
|olfactory bulb development|
|olfactory lobe development|
|embryonic digestive tract development|
|cell differentiation involved in kidney development|
|pituitary gland development|
|branching involved in ureteric bud morphogenesis|
|forebrain neuron differentiation|
|cranial nerve development|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|embryonic digit morphogenesis|
|nephron tubule morphogenesis|
|somatic stem cell population maintenance|
|nephron epithelium morphogenesis|
|forebrain generation of neurons|
|nephron morphogenesis|
|renal tubule morphogenesis|
|ventricular septum development|
|diencephalon development|
|nephron tubule development|
|nerve development|
|renal tubule development|
|beta-catenin binding|
|metanephros development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|mesonephros development|
|nephron epithelium development|
|cardiac septum development|
|developmental growth involved in morphogenesis|
|ear morphogenesis|
|endocrine system development|
|nephron development|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|cardiac ventricle development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|digestive tract development|
|stem cell population maintenance|
|maintenance of cell number|
|digestive system development|
|limb morphogenesis|
|appendage morphogenesis|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|cardiac chamber development|
|positive regulation of Wnt signaling pathway|
|central nervous system neuron differentiation|
|limb development|
|appendage development|
|gonad development|
|development of primary sexual characteristics|
|ear development|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|sensory organ morphogenesis|
|telencephalon development|
|sex differentiation|
|kidney development|
|renal system development|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|urogenital system development|
|regulation of Wnt signaling pathway|
|forebrain development|
|developmental growth|
|growth|
|gland development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|heart development|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|tube morphogenesis|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|brain development|
|head development|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.99|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.81|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.75|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16054
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SALL1 Expression in NALM6 Cells: -1.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>