SALL1
Gene Information
- Official Symbol: SALL1
- Official Name: spalt like transcription factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6299
- UniProt: Q9NSC2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: Transcriptional repressor involved in organogenesis. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| inductive cell-cell signaling |
| olfactory bulb mitral cell layer development |
| olfactory nerve development |
| ureteric bud invasion |
| metanephric renal vesicle formation |
| ureteric bud elongation |
| renal vesicle formation |
| mesenchymal to epithelial transition involved in metanephros morphogenesis |
| outer ear morphogenesis |
| metanephric renal vesicle morphogenesis |
| chromocenter |
| renal vesicle morphogenesis |
| renal vesicle development |
| olfactory bulb interneuron differentiation |
| mesenchymal to epithelial transition |
| cell differentiation involved in metanephros development |
| metanephric nephron morphogenesis |
| adrenal gland development |
| heterochromatin |
| metanephros morphogenesis |
| developmental induction |
| epithelial cell differentiation involved in kidney development |
| metanephric nephron development |
| olfactory bulb development |
| olfactory lobe development |
| embryonic digestive tract development |
| cell differentiation involved in kidney development |
| pituitary gland development |
| branching involved in ureteric bud morphogenesis |
| forebrain neuron differentiation |
| cranial nerve development |
| ureteric bud morphogenesis |
| mesonephric tubule morphogenesis |
| embryonic digit morphogenesis |
| nephron tubule morphogenesis |
| somatic stem cell population maintenance |
| nephron epithelium morphogenesis |
| forebrain generation of neurons |
| nephron morphogenesis |
| renal tubule morphogenesis |
| ventricular septum development |
| diencephalon development |
| nephron tubule development |
| nerve development |
| renal tubule development |
| beta-catenin binding |
| metanephros development |
| kidney morphogenesis |
| ureteric bud development |
| mesonephric epithelium development |
| mesonephric tubule development |
| mesonephros development |
| nephron epithelium development |
| cardiac septum development |
| developmental growth involved in morphogenesis |
| ear morphogenesis |
| endocrine system development |
| nephron development |
| embryonic appendage morphogenesis |
| embryonic limb morphogenesis |
| cardiac ventricle development |
| kidney epithelium development |
| branching morphogenesis of an epithelial tube |
| digestive tract development |
| stem cell population maintenance |
| maintenance of cell number |
| digestive system development |
| limb morphogenesis |
| appendage morphogenesis |
| morphogenesis of a branching epithelium |
| morphogenesis of a branching structure |
| cardiac chamber development |
| positive regulation of Wnt signaling pathway |
| central nervous system neuron differentiation |
| limb development |
| appendage development |
| gonad development |
| development of primary sexual characteristics |
| ear development |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| sensory organ morphogenesis |
| telencephalon development |
| sex differentiation |
| kidney development |
| renal system development |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| urogenital system development |
| regulation of Wnt signaling pathway |
| forebrain development |
| developmental growth |
| growth |
| gland development |
| reproductive structure development |
| reproductive system development |
| morphogenesis of an epithelium |
| embryonic organ development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| heart development |
| sensory organ development |
| tissue morphogenesis |
| embryonic morphogenesis |
| tube morphogenesis |
| developmental process involved in reproduction |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| brain development |
| head development |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| animal organ morphogenesis |
| embryo development |
| central nervous system development |
| neuron differentiation |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| positive regulation of cell communication |
| positive regulation of signaling |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Asunaprenir 3μM R07 exp336 | -1.99 |
| LB-100 4.1μM R02 exp72 | -1.81 |
| Alpha-Amanitin 0.5μM R00 exp5 | -1.75 |
| iCRT14 30μM R08 exp492 | 1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16054
- Expression level (log2 read counts): -1.3
Expression Distribution
SALL1 Expression in NALM6 Cells: -1.3
