SAMD4B [The Human Chemical-Genetic Interaction Map Project]

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======= SAMD4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAMD4B
  * **<color #00a2e8>Official Name</color>**: sterile alpha motif domain containing 4B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55095|55095]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5PRF9|Q5PRF9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAMD4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAMD4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619231|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 2|
|SAM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation repressor activity|
|nuclear-transcribed mRNA poly(A) tail shortening|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|P-body|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|mRNA binding|
|regulation of mRNA stability|
|regulation of RNA stability|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|regulation of mRNA metabolic process|
|regulation of translation|
|nucleobase-containing compound catabolic process|
|regulation of cellular amide metabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|negative regulation of protein metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.85|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.74|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.74|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.76|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.79|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.8|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.82|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.88|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.89|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.01|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.07|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.11|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.18|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.34|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.34|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.28|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.46|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.559|
|[[:human genes:m:mnt|MNT]]|0.469|
|[[:human genes:a:axin1|AXIN1]]|0.418|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|3/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1095
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAMD4B Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>