SAMD4B

Entrez Summary: N/A
UniProt Summary: Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.85
Diepoxybutane 3μM R07 exp354	1.74
Fas-L 44ng/ml R08 exp482	1.74
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.76
Apcin 50 to 100μM on day4 R04 exp176	1.79
Heregulin-B 44ng/ml R08 exp486	1.8
BH1 1μM R04 exp169	1.82
All-trans-Retinoic-Acid 40μM R07 exp334	1.88
GSK-J5 1.5μM R08 exp484	1.89
Rifampicin 10μM R00 exp32	2.01
3-Bromopyruvate 7μM R04 exp175	2.07
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.11
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	2.18
5-Fluorouracil 20μM R00 exp2	2.34
UM0011500 10μM R05 exp246	2.34
Actinomycin-D 0.001μM R00 exp3	3.28
TRAIL 5ng/ml R00 exp35	3.46
TRAIL 50ng/ml R00 exp36	3.6

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	3/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SAM 2
SAM 1

translation repressor activity
nuclear-transcribed mRNA poly(A) tail shortening
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
P-body
negative regulation of translation
negative regulation of cellular amide metabolic process
mRNA binding
regulation of mRNA stability
regulation of RNA stability
nuclear-transcribed mRNA catabolic process
regulation of mRNA catabolic process
mRNA catabolic process
RNA catabolic process
regulation of mRNA metabolic process
regulation of translation
nucleobase-containing compound catabolic process
regulation of cellular amide metabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
posttranscriptional regulation of gene expression
mRNA metabolic process
regulation of cellular catabolic process
cellular macromolecule catabolic process
regulation of catabolic process
negative regulation of cellular protein metabolic process
macromolecule catabolic process
negative regulation of protein metabolic process
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process
cellular catabolic process