SAMM50 [The Human Chemical-Genetic Interaction Map Project]

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======= SAMM50 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAMM50
  * **<color #00a2e8>Official Name</color>**: SAMM50 sorting and assembly machinery component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25813|25813]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y512|Q9Y512]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAMM50&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAMM50|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612058|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes (PubMed:22252321, PubMed:25781180). Required for the assembly of TOMM40 into the TOM complex (PubMed:15644312). {ECO:0000269|PubMed:15644312, ECO:0000269|PubMed:22252321, ECO:0000269|PubMed:25781180}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bac surface Ag|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein insertion into mitochondrial outer membrane|
|SAM complex|
|outer mitochondrial membrane organization|
|establishment of protein localization to mitochondrial membrane|
|protein insertion into mitochondrial membrane|
|cristae formation|
|protein insertion into membrane|
|inner mitochondrial membrane organization|
|protein targeting to mitochondrion|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial respiratory chain complex assembly|
|mitochondrial membrane organization|
|protein import|
|mitochondrial outer membrane|
|mitochondrial transport|
|establishment of protein localization to membrane|
|protein targeting|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to membrane|
|protein localization to organelle|
|cellular protein-containing complex assembly|
|membrane organization|
|intracellular protein transport|
|mitochondrion|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.12|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.83|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.77|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.76|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1022
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAMM50 Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>