SAMM50

Entrez Summary: This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011].
UniProt Summary: Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes (PubMed:22252321, PubMed:25781180). Required for the assembly of TOMM40 into the TOM complex (PubMed:15644312). {ECO:0000269|PubMed:15644312, ECO:0000269|PubMed:22252321, ECO:0000269|PubMed:25781180}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein insertion into mitochondrial outer membrane
SAM complex
outer mitochondrial membrane organization
establishment of protein localization to mitochondrial membrane
protein insertion into mitochondrial membrane
cristae formation
protein insertion into membrane
inner mitochondrial membrane organization
protein targeting to mitochondrion
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial respiratory chain complex assembly
mitochondrial membrane organization
protein import
mitochondrial outer membrane
mitochondrial transport
establishment of protein localization to membrane
protein targeting
establishment of protein localization to organelle
mitochondrion organization
protein localization to membrane
protein localization to organelle
cellular protein-containing complex assembly
membrane organization
intracellular protein transport
mitochondrion
protein transport
intracellular transport
peptide transport
protein-containing complex assembly
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
protein-containing complex subunit organization