SAMSN1

Entrez Summary: N/A
UniProt Summary: Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). {ECO:0000250, ECO:0000269|PubMed:15381729}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of B cell activation
phosphotyrosine residue binding
negative regulation of adaptive immune response
negative regulation of peptidyl-tyrosine phosphorylation
ruffle
negative regulation of lymphocyte activation
negative regulation of immune response
regulation of adaptive immune response
negative regulation of leukocyte activation
negative regulation of cell activation
regulation of B cell activation
regulation of peptidyl-tyrosine phosphorylation
negative regulation of protein phosphorylation
negative regulation of immune system process
negative regulation of phosphorylation
regulation of lymphocyte activation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of leukocyte activation
regulation of cell activation
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
regulation of immune response
RNA binding
regulation of protein phosphorylation
regulation of phosphorylation
negative regulation of response to stimulus
regulation of immune system process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process