SAP30 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= SAP30 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAP30
  * **<color #00a2e8>Official Name</color>**: Sin3A associated protein 30
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8819|8819]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75446|O75446]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAP30&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAP30|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603378|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. {ECO:0000250|UniProtKB:O88574, ECO:0000269|PubMed:9651585}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone deacetylase activity|
|histone deacetylase complex|
|histone deacetylation|
|skeletal muscle cell differentiation|
|protein deacetylation|
|protein deacylation|
|macromolecule deacylation|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|transcription corepressor activity|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|histone modification|
|covalent chromatin modification|
|muscle structure development|
|chromatin organization|
|negative regulation of transcription by RNA polymerase II|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.12|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.08|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.02|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.96|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.95|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.9|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.85|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.85|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.78|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.77|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.73|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.71|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.7|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.75|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15604
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAP30 Expression in NALM6 Cells: 4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>