SAP30

Entrez Summary: N/A
UniProt Summary: Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. {ECO:0000250|UniProtKB:O88574, ECO:0000269|PubMed:9651585}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
3-Bromopyruvate 7μM R04 exp175	-2.12
Clomiphene 4.4μM R02 exp68	-2.08
UM131593 0.2μM R03 exp106	-2.02
S-trityl-L-cysteine 0.5μM R05 exp243	-1.96
Vemurafenib 6.6μM R08 exp434	-1.95
UM0129480 7μM R02 exp85	-1.9
GSK626616 14μM R08 exp485	-1.85
Prochlorperazine 5.2μM R02 exp77	-1.85
Vinblastine 0.002μM R01 exp60	-1.78
Apcin 25μM plus proTAME 2μM R04 exp177	-1.77
MS023 2μM R03 exp134	-1.73
Benzoate 10000μM R08 exp455	-1.71
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.7
THZ531 0.225μM R08 exp444	1.75
ML-792 0.2μM R08 exp505	1.78

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histone deacetylase activity
histone deacetylase complex
histone deacetylation
skeletal muscle cell differentiation
protein deacetylation
protein deacylation
macromolecule deacylation
skeletal muscle tissue development
skeletal muscle organ development
transcription corepressor activity
striated muscle tissue development
muscle organ development
muscle tissue development
histone modification
covalent chromatin modification
muscle structure development
chromatin organization
negative regulation of transcription by RNA polymerase II
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression
tissue development