SAPCD2 [The Human Chemical-Genetic Interaction Map Project]

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======= SAPCD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAPCD2
  * **<color #00a2e8>Official Name</color>**: suppressor APC domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=89958|89958]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UD0|Q86UD0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAPCD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAPCD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612057|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). {ECO:0000250|UniProtKB:Q9D818, ECO:0000269|PubMed:23576022, ECO:0000269|PubMed:23704824, ECO:0000269|PubMed:26766442}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Suppressor APC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein localization to cell cortex|
|symmetric cell division|
|apical cortex|
|regulation of protein localization to cell cortex|
|apical junction complex|
|negative regulation of protein localization to cell periphery|
|establishment of mitotic spindle orientation|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|establishment of spindle localization|
|spindle localization|
|microtubule cytoskeleton organization involved in mitosis|
|regulation of establishment of planar polarity|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|establishment of cell polarity|
|bicellular tight junction|
|regulation of morphogenesis of an epithelium|
|establishment or maintenance of cell polarity|
|regulation of animal organ morphogenesis|
|apical plasma membrane|
|establishment of organelle localization|
|microtubule cytoskeleton organization|
|cell division|
|regulation of cellular protein localization|
|organelle localization|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|nucleolus|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|cell cycle process|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|cell cycle|
|regulation of cell population proliferation|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9910
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAPCD2 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>