SAPCD2

Entrez Summary: N/A
UniProt Summary: Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). {ECO:0000250|UniProtKB:Q9D818, ECO:0000269|PubMed:23576022, ECO:0000269|PubMed:23704824, ECO:0000269|PubMed:26766442}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of protein localization to cell cortex
symmetric cell division
apical cortex
regulation of protein localization to cell cortex
apical junction complex
negative regulation of protein localization to cell periphery
establishment of mitotic spindle orientation
establishment of mitotic spindle localization
establishment of spindle orientation
establishment of spindle localization
spindle localization
microtubule cytoskeleton organization involved in mitosis
regulation of establishment of planar polarity
negative regulation of cellular protein localization
regulation of protein localization to cell periphery
establishment of cell polarity
bicellular tight junction
regulation of morphogenesis of an epithelium
establishment or maintenance of cell polarity
regulation of animal organ morphogenesis
apical plasma membrane
establishment of organelle localization
microtubule cytoskeleton organization
cell division
regulation of cellular protein localization
organelle localization
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
nucleolus
positive regulation of cell population proliferation
regulation of cellular localization
cell cycle process
regulation of protein localization
regulation of anatomical structure morphogenesis
cytoskeleton organization
cell cycle
regulation of cell population proliferation
establishment of localization in cell