SAR1B

Gene Information

Official Symbol: SAR1B
Official Name: secretion associated Ras related GTPase 1B
Aliases and Previous Symbols: N/A
Entrez ID: 51128
UniProt: Q9Y6B6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010].
UniProt Summary: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17916
Expression level (log2 read counts): 6.52

Expression Distribution

G-alpha
Ras
SRPRB
Arf
Miro

regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis
regulation of COPII vesicle coating
regulation of vesicle targeting, to, from or within Golgi
positive regulation of protein exit from endoplasmic reticulum
COPII vesicle coat
regulation of ER to Golgi vesicle-mediated transport
regulation of protein exit from endoplasmic reticulum
endoplasmic reticulum exit site
ER to Golgi transport vesicle membrane
COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
vesicle targeting
Golgi cisterna membrane
vesicle budding from membrane
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
positive regulation of intracellular protein transport
establishment of vesicle localization
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
vesicle localization
antigen processing and presentation of peptide antigen
positive regulation of intracellular transport
endoplasmic reticulum to Golgi vesicle-mediated transport
antigen processing and presentation
regulation of intracellular protein transport
vesicle organization
positive regulation of cellular protein localization
GTPase activity
regulation of intracellular transport
establishment of organelle localization
Golgi vesicle transport
GTP binding
positive regulation of protein transport