SART1 [The Human Chemical-Genetic Interaction Map Project]

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======= SART1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SART1
  * **<color #00a2e8>Official Name</color>**: spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9092|9092]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43290|O43290]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SART1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SART1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605941|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SART-1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of 5S rRNA|
|positive regulation of cytotoxic T cell differentiation|
|regulation of cytotoxic T cell differentiation|
|mRNA cis splicing, via spliceosome|
|U4/U6 x U5 tri-snRNP complex|
|spliceosomal snRNP assembly|
|U2-type precatalytic spliceosome|
|Cajal body|
|positive regulation of T cell differentiation|
|catalytic step 2 spliceosome|
|positive regulation of lymphocyte differentiation|
|regulation of T cell differentiation|
|positive regulation of leukocyte differentiation|
|regulation of lymphocyte differentiation|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|rRNA processing|
|positive regulation of leukocyte cell-cell adhesion|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|ribosome biogenesis|
|RNA splicing, via transesterification reactions|
|regulation of T cell activation|
|positive regulation of lymphocyte activation|
|ncRNA processing|
|regulation of cell-cell adhesion|
|RNA splicing|
|nuclear speck|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of hemopoiesis|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of cell adhesion|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|positive regulation of cell differentiation|
|Golgi apparatus|
|positive regulation of immune system process|
|positive regulation of developmental process|
|RNA binding|
|protein-containing complex assembly|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.86|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.77|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-2.76|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.41|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.4|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.3|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.23|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.13|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.12|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.1|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.06|
|[[:results:exp539|42°C R08 exp539]]|-2.01|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.97|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.95|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.93|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.88|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.87|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.81|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.76|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.74|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.71|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.74|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.74|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.76|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.86|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.9|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.94|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.94|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.95|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.97|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|2.08|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|2.08|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.13|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.13|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.17|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.21|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.31|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.65|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.72|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|2.84|
|[[:results:exp392|PT-1 25μM R07 exp392]]|2.95|
|[[:results:exp331|A-769662 20μM R07 exp331]]|3.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl35|RPL35]]|0.514|
|[[:human genes:p:pole|POLE]]|0.503|
|[[:human genes:t:ticrr|TICRR]]|0.502|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.5|
|[[:human genes:p:polr2j3|POLR2J3]]|0.5|
|[[:human genes:n:nupl1|NUPL1]]|0.494|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.49|
|[[:human genes:p:psmb4|PSMB4]]|0.483|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.479|
|[[:human genes:p:psmd3|PSMD3]]|0.478|
|[[:human genes:s:supt5h|SUPT5H]]|0.473|
|[[:human genes:n:nup160|NUP160]]|0.472|
|[[:human genes:s:slc6a17|SLC6A17]]|0.464|
|[[:human genes:w:wdr75|WDR75]]|0.462|
|[[:human genes:r:rnf113a|RNF113A]]|0.46|
|[[:human genes:t:tceb3c|TCEB3C]]|0.459|
|[[:human genes:n:ngdn|NGDN]]|0.452|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.451|
|[[:human genes:c:ctage4|CTAGE4]]|0.451|
|[[:human genes:s:sf3a1|SF3A1]]|0.451|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.45|
|[[:human genes:t:timeless|TIMELESS]]|0.45|
|[[:human genes:p:pwp2|PWP2]]|0.447|
|[[:human genes:s:stil|STIL]]|0.445|
|[[:human genes:p:psma6|PSMA6]]|0.445|
|[[:human genes:r:rad51|RAD51]]|0.444|
|[[:human genes:e:exosc9|EXOSC9]]|0.443|
|[[:human genes:r:rrp15|RRP15]]|0.443|
|[[:human genes:c:cbwd3|CBWD3]]|0.442|
|[[:human genes:r:relt|RELT]]|0.442|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.442|
|[[:human genes:p:pan3|PAN3]]|0.441|
|[[:human genes:c:chd4|CHD4]]|0.441|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.44|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.439|
|[[:human genes:f:fam25b|FAM25B]]|0.437|
|[[:human genes:p:psmb2|PSMB2]]|0.436|
|[[:human genes:c:copb1|COPB1]]|0.435|
|[[:human genes:i:iscu|ISCU]]|0.432|
|[[:human genes:c:chaf1a|CHAF1A]]|0.431|
|[[:human genes:c:ccna2|CCNA2]]|0.431|
|[[:human genes:l:lad1|LAD1]]|0.43|
|[[:human genes:c:cbwd6|CBWD6]]|0.427|
|[[:human genes:n:nol12|NOL12]]|0.427|
|[[:human genes:k:krt78|KRT78]]|0.426|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.425|
|[[:human genes:z:znf655|ZNF655]]|0.425|
|[[:human genes:v:vasn|VASN]]|0.424|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.424|
|[[:human genes:n:nol9|NOL9]]|0.423|
|[[:human genes:z:znf830|ZNF830]]|0.423|
|[[:human genes:c:cdc45|CDC45]]|0.423|
|[[:human genes:i:igfn1|IGFN1]]|0.422|
|[[:human genes:c:c14orf93|C14orf93]]|0.42|
|[[:human genes:b:bysl|BYSL]]|0.417|
|[[:human genes:n:npipb5|NPIPB5]]|0.417|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.416|
|[[:human genes:o:osbp|OSBP]]|0.415|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.415|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.415|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.415|
|[[:human genes:t:trappc11|TRAPPC11]]|0.414|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.414|
|[[:human genes:r:rpl6|RPL6]]|0.414|
|[[:human genes:c:cbwd5|CBWD5]]|0.413|
|[[:human genes:g:golga8o|GOLGA8O]]|0.412|
|[[:human genes:p:prim1|PRIM1]]|0.412|
|[[:human genes:h:hivep3|HIVEP3]]|0.412|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.412|
|[[:human genes:p:prpf8|PRPF8]]|0.411|
|[[:human genes:c:ccdc94|CCDC94]]|0.41|
|[[:human genes:r:rps2|RPS2]]|0.41|
|[[:human genes:n:nbpf16|NBPF16]]|0.41|
|[[:human genes:n:ncapg|NCAPG]]|0.409|
|[[:human genes:p:psmc2|PSMC2]]|0.409|
|[[:human genes:p:psmb3|PSMB3]]|0.408|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.408|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.408|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.408|
|[[:human genes:t:twistnb|TWISTNB]]|0.407|
|[[:human genes:s:slc4a1|SLC4A1]]|0.407|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.407|
|[[:human genes:n:nup43|NUP43]]|0.407|
|[[:human genes:e:eif4a3|EIF4A3]]|0.405|
|[[:human genes:l:lrr1|LRR1]]|0.405|
|[[:human genes:w:wdr43|WDR43]]|0.405|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.405|
|[[:human genes:r:rrp7a|RRP7A]]|0.404|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.403|
|[[:human genes:t:tonsl|TONSL]]|0.401|
|[[:human genes:s:strn|STRN]]|0.401|
|[[:human genes:c:copg1|COPG1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 415/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|14/28|
|blood|19/28|
|bone|9/26|
|breast|17/33|
|central nervous system|33/56|
|cervix|2/4|
|colorectal|8/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|15/21|
|liver|12/20|
|lung|36/75|
|lymphocyte|11/16|
|ovary|16/26|
|pancreas|10/24|
|peripheral nervous system|7/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|13/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|16/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 622
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SART1 Expression in NALM6 Cells: 6.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>