SART1

Official Symbol: SART1
Official Name: spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
Aliases and Previous Symbols: N/A
Entrez ID: 9092
UniProt: O43290
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nocodazole 0.1μM R03 exp94	-2.86
CFI-400945 25μM R08 exp469	-2.77
Vinblastine 0.2μM R03 exp108	-2.76
JQ1 0.8μM R08 exp435	-2.41
Arsenate 40μM R06 exp264	-2.4
MLN-4924 2μM R00 exp22	-2.3
Brefeldin A 0.02μM R00 exp8	-2.23
GSK461364A 0.1μM R03 exp126	-2.13
TRAIL 50ng/ml R00 exp36	-2.12
Nocodazole 0.2μM R02 exp64	-2.1
THZ1 0.06μM R08 exp531	-2.06
42°C R08 exp539	-2.01
Dinaciclib 0.007μM R07 exp355	-1.97
Oligomycin-A 20μM R00 exp26	-1.95
R-DABN 8μM R03 exp111	-1.93
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.88
DABN 20μM R00 exp17	-1.87
5-Azacytidine 2μM R07 exp330	-1.81
Rotenone 20μM R00 exp34	-1.76
Atovaquone 15μM R08 exp451	-1.74
Losmapimod 1μM R07 exp376	1.71
Cyclosporin-A 3μM R07 exp348	1.74
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.74
GSK2606414 1μM R05 exp236	1.76
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.86
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.9
FK-506 30μM R07 exp359	1.94
Tenofovir 10μM R07 exp405	1.94
Myriocin 25μM R06 exp293	1.95
WYE-354 6μM R02 exp90	1.97
Golgicide-A 2μM R03 exp121	2.08
UM0130462 0.025 to 0.035μM day4 R05 exp247	2.08
Trichostatin-A 0.06μM R07 exp415	2.13
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.13
FBS-Wisent 0.1 R07 exp426	2.17
Ibrutinib 10μM R08 exp442	2.21
Dorsomorphin 5μM R07 exp357	2.31
VHL-ligand-1 20μM R07 exp421	2.65
proTAME 5μM R04 exp187	2.72
MKC9989 10μM R03 exp133	2.84
PT-1 25μM R07 exp392	2.95
A-769662 20μM R07 exp331	3.25

Global Fraction of Cell Lines Where Essential: 415/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	14/28
blood	19/28
bone	9/26
breast	17/33
central nervous system	33/56
cervix	2/4
colorectal	8/17
esophagus	7/13
fibroblast	1/1
gastric	10/16
kidney	15/21
liver	12/20
lung	36/75
lymphocyte	11/16
ovary	16/26
pancreas	10/24
peripheral nervous system	7/16
plasma cell	10/15
prostate	1/1
skin	13/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	6/22
urinary tract	16/29
uterus	4/5

Expression Distribution

maturation of 5S rRNA
positive regulation of cytotoxic T cell differentiation
regulation of cytotoxic T cell differentiation
mRNA cis splicing, via spliceosome
U4/U6 x U5 tri-snRNP complex
spliceosomal snRNP assembly
U2-type precatalytic spliceosome
Cajal body
positive regulation of T cell differentiation
catalytic step 2 spliceosome
positive regulation of lymphocyte differentiation
regulation of T cell differentiation
positive regulation of leukocyte differentiation
regulation of lymphocyte differentiation
positive regulation of hemopoiesis
positive regulation of T cell activation
rRNA processing
positive regulation of leukocyte cell-cell adhesion
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
positive regulation of cell-cell adhesion
regulation of leukocyte differentiation
regulation of leukocyte cell-cell adhesion
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
ribosome biogenesis
RNA splicing, via transesterification reactions
regulation of T cell activation
positive regulation of lymphocyte activation
ncRNA processing
regulation of cell-cell adhesion
RNA splicing
nuclear speck
positive regulation of cell adhesion
positive regulation of leukocyte activation
positive regulation of cell activation
regulation of hemopoiesis
ribonucleoprotein complex biogenesis
ncRNA metabolic process