SASH1 [The Human Chemical-Genetic Interaction Map Project]

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======= SASH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SASH1
  * **<color #00a2e8>Official Name</color>**: SAM and SH3 domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23328|23328]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94885|O94885]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SASH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SASH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607955|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May have a role in a signaling pathway. Could act as a tumor suppressor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 2|
|SAM 1|
|SLY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein autoubiquitination|
|positive regulation of lipopolysaccharide-mediated signaling pathway|
|regulation of protein K63-linked ubiquitination|
|mitogen-activated protein kinase kinase kinase binding|
|regulation of protein polyubiquitination|
|regulation of lipopolysaccharide-mediated signaling pathway|
|positive regulation of p38MAPK cascade|
|regulation of p38MAPK cascade|
|molecular adaptor activity|
|positive regulation of JUN kinase activity|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of JUN kinase activity|
|positive regulation of endothelial cell migration|
|regulation of NIK/NF-kappaB signaling|
|positive regulation of JNK cascade|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of vasculature development|
|regulation of JNK cascade|
|protein C-terminus binding|
|regulation of protein ubiquitination|
|regulation of epithelial cell migration|
|regulation of protein modification by small protein conjugation or removal|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|positive regulation of MAP kinase activity|
|regulation of angiogenesis|
|protein polyubiquitination|
|regulation of vasculature development|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|positive regulation of response to biotic stimulus|
|protein kinase binding|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|positive regulation of kinase activity|
|protein-containing complex|
|positive regulation of response to external stimulus|
|positive regulation of transferase activity|
|protein ubiquitination|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of transferase activity|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7047
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SASH1 Expression in NALM6 Cells: 2.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>