SASH1

Gene Information

Official Symbol: SASH1
Official Name: SAM and SH3 domain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 23328
UniProt: O94885
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients. [provided by RefSeq, Oct 2016].
UniProt Summary: May have a role in a signaling pathway. Could act as a tumor suppressor.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7047
Expression level (log2 read counts): 2.21

Expression Distribution

SAM 2
SAM 1
SLY

regulation of protein autoubiquitination
positive regulation of lipopolysaccharide-mediated signaling pathway
regulation of protein K63-linked ubiquitination
mitogen-activated protein kinase kinase kinase binding
regulation of protein polyubiquitination
regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of p38MAPK cascade
regulation of p38MAPK cascade
molecular adaptor activity
positive regulation of JUN kinase activity
positive regulation of NIK/NF-kappaB signaling
regulation of JUN kinase activity
positive regulation of endothelial cell migration
regulation of NIK/NF-kappaB signaling
positive regulation of JNK cascade
positive regulation of epithelial cell migration
regulation of endothelial cell migration
positive regulation of angiogenesis
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
positive regulation of vasculature development
regulation of JNK cascade
protein C-terminus binding
regulation of protein ubiquitination
regulation of epithelial cell migration
regulation of protein modification by small protein conjugation or removal
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
positive regulation of MAP kinase activity
regulation of angiogenesis
protein polyubiquitination
regulation of vasculature development
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
positive regulation of response to biotic stimulus
protein kinase binding
positive regulation of cell migration
positive regulation of multi-organism process
regulation of protein serine/threonine kinase activity
positive regulation of cell motility