SASH3 [The Human Chemical-Genetic Interaction Map Project]

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======= SASH3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SASH3
  * **<color #00a2e8>Official Name</color>**: SAM and SH3 domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54440|54440]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75995|O75995]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SASH3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SASH3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300441|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene contains a Src homology-3 (SH3) domain and a sterile alpha motif (SAM), both of which are found in proteins involved in cell signaling. This protein may function as a signaling adapter protein in lymphocytes.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a signaling adapter protein in lymphocytes. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 2|
|SH3 2|
|SAM 1|
|SLY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of T cell cytokine production|
|positive regulation of interleukin-4 production|
|regulation of interleukin-4 production|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|homeostasis of number of cells within a tissue|
|positive regulation of interleukin-2 production|
|regulation of T cell cytokine production|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of interleukin-10 production|
|positive regulation of B cell proliferation|
|positive regulation of immunoglobulin production|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of organ growth|
|positive regulation of T cell mediated immunity|
|regulation of interleukin-10 production|
|regulation of interleukin-2 production|
|positive regulation of cytokine production involved in immune response|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of B cell proliferation|
|regulation of alpha-beta T cell differentiation|
|regulation of immunoglobulin production|
|positive regulation of interferon-gamma production|
|regulation of T cell mediated immunity|
|positive regulation of T cell differentiation|
|regulation of cytokine production involved in immune response|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|regulation of organ growth|
|positive regulation of T cell proliferation|
|positive regulation of production of molecular mediator of immune response|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|regulation of lymphocyte mediated immunity|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|positive regulation of developmental growth|
|positive regulation of hemopoiesis|
|tissue homeostasis|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|positive regulation of cell-cell adhesion|
|positive regulation of growth|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|regulation of developmental growth|
|anatomical structure homeostasis|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of immune effector process|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of growth|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|positive regulation of cell differentiation|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of developmental process|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-2.02|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.99|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.97|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.87|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.72|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13516
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SASH3 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>