SASH3
Gene Information
- Official Symbol: SASH3
- Official Name: SAM and SH3 domain containing 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 54440
- UniProt: O75995
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene contains a Src homology-3 (SH3) domain and a sterile alpha motif (SAM), both of which are found in proteins involved in cell signaling. This protein may function as a signaling adapter protein in lymphocytes.[provided by RefSeq, Sep 2009].
- UniProt Summary: May function as a signaling adapter protein in lymphocytes. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| SAM 2 |
| SH3 2 |
| SAM 1 |
| SLY |
GO Terms
| positive regulation of T cell cytokine production |
| positive regulation of interleukin-4 production |
| regulation of interleukin-4 production |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| homeostasis of number of cells within a tissue |
| positive regulation of interleukin-2 production |
| regulation of T cell cytokine production |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of interleukin-10 production |
| positive regulation of B cell proliferation |
| positive regulation of immunoglobulin production |
| positive regulation of alpha-beta T cell differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of organ growth |
| positive regulation of T cell mediated immunity |
| regulation of interleukin-10 production |
| regulation of interleukin-2 production |
| positive regulation of cytokine production involved in immune response |
| positive regulation of alpha-beta T cell activation |
| regulation of CD4-positive, alpha-beta T cell activation |
| regulation of B cell proliferation |
| regulation of alpha-beta T cell differentiation |
| regulation of immunoglobulin production |
| positive regulation of interferon-gamma production |
| regulation of T cell mediated immunity |
| positive regulation of T cell differentiation |
| regulation of cytokine production involved in immune response |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| regulation of organ growth |
| positive regulation of T cell proliferation |
| positive regulation of production of molecular mediator of immune response |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte mediated immunity |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| regulation of production of molecular mediator of immune response |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of leukocyte differentiation |
| regulation of tumor necrosis factor production |
| regulation of lymphocyte mediated immunity |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of T cell proliferation |
| regulation of adaptive immune response |
| positive regulation of B cell activation |
| regulation of lymphocyte differentiation |
| positive regulation of developmental growth |
| positive regulation of hemopoiesis |
| tissue homeostasis |
| homeostasis of number of cells |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| positive regulation of cell-cell adhesion |
| positive regulation of growth |
| regulation of leukocyte differentiation |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| multicellular organismal homeostasis |
| regulation of developmental growth |
| anatomical structure homeostasis |
| positive regulation of lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of immune effector process |
| regulation of lymphocyte activation |
| regulation of leukocyte activation |
| regulation of cell activation |
| regulation of growth |
| regulation of cell adhesion |
| regulation of cytokine production |
| positive regulation of immune response |
| positive regulation of cell population proliferation |
| positive regulation of cell differentiation |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of developmental process |
| regulation of cell population proliferation |
| homeostatic process |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| OICR-9429 10μM R03 exp142 | -2.02 |
| SNS-032 25μM R07 exp401 | -1.99 |
| PF-06409577 20μM R07 exp389 | -1.97 |
| Arsenate 40μM R06 exp264 | -1.87 |
| ABT-702 5μM plus Deferoxamine 11μM R07 exp321 | -1.72 |
| Docetaxel 0.002μM R01 exp45 | 2.28 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13516
- Expression level (log2 read counts): 7.39
Expression Distribution
SASH3 Expression in NALM6 Cells: 7.39
