SAT2

Entrez Summary: N/A
UniProt Summary: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine » N(1)acetylspermine = putrescine.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
THZ531 0.11μM R07 exp409	-1.89
Lead acetate 2000μM R08 exp497	1.71

nor-spermidine metabolic process
spermine acetylation
putrescine acetylation
spermidine binding
polyamine acetylation
spermidine acetylation
putrescine catabolic process
diamine N-acetyltransferase activity
polyamine catabolic process
spermine metabolic process
putrescine metabolic process
N-acetyltransferase activity
spermidine metabolic process
polyamine metabolic process
cellular biogenic amine catabolic process
amine catabolic process
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
ammonium ion metabolic process
drug metabolic process
organonitrogen compound catabolic process
identical protein binding
organic substance catabolic process