SCAF8 [The Human Chemical-Genetic Interaction Map Project]

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======= SCAF8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCAF8
  * **<color #00a2e8>Official Name</color>**: SR-related CTD associated factor 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22828|22828]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPN6|Q9UPN6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCAF8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCAF8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616024|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in mRNA processing. {ECO:0000269|PubMed:11101529}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|DUF618|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase core enzyme binding|
|negative regulation of termination of RNA polymerase II transcription|
|negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled|
|negative regulation of DNA-templated transcription, termination|
|regulation of termination of RNA polymerase II transcription, poly(A)-coupled|
|regulation of termination of RNA polymerase II transcription|
|RNA polymerase II C-terminal domain phosphoserine binding|
|regulation of DNA-templated transcription, termination|
|mRNA polyadenylation|
|RNA polyadenylation|
|positive regulation of DNA-templated transcription, elongation|
|RNA polymerase II complex binding|
|termination of RNA polymerase II transcription|
|regulation of DNA-templated transcription, elongation|
|negative regulation of protein complex disassembly|
|DNA-templated transcription, termination|
|mRNA 3-end processing|
|spliceosomal complex|
|nuclear matrix|
|regulation of protein complex disassembly|
|RNA 3-end processing|
|mRNA binding|
|RNA splicing|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|negative regulation of cellular component organization|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.69|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.54|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.47|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.38|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.35|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.3|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.21|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.18|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.1|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.09|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.05|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.01|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.98|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.82|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.82|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.78|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.76|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.76|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.72|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.7|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.7|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.7|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.84|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.16|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.29|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.35|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.35|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.79|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:znf410|ZNF410]]|0.522|
|[[:human genes:a:ago2|AGO2]]|0.508|
|[[:human genes:x:xpo6|XPO6]]|0.495|
|[[:human genes:i:id3|ID3]]|0.488|
|[[:human genes:e:erg|ERG]]|0.486|
|[[:human genes:s:ssbp2|SSBP2]]|0.475|
|[[:human genes:n:nsd1|NSD1]]|0.471|
|[[:human genes:c:celf1|CELF1]]|0.462|
|[[:human genes:b:bap1|BAP1]]|0.451|
|[[:human genes:c:ccdc101|CCDC101]]|0.434|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.432|
|[[:human genes:b:brpf1|BRPF1]]|0.431|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.431|
|[[:human genes:r:runx1|RUNX1]]|0.43|
|[[:human genes:e:egln1|EGLN1]]|0.426|
|[[:human genes:d:ddx5|DDX5]]|0.423|
|[[:human genes:a:asxl2|ASXL2]]|0.423|
|[[:human genes:c:cbfb|CBFB]]|0.422|
|[[:human genes:m:maml1|MAML1]]|0.421|
|[[:human genes:m:mef2c|MEF2C]]|0.418|
|[[:human genes:t:trim28|TRIM28]]|0.414|
|[[:human genes:t:tle4|TLE4]]|0.41|
|[[:human genes:h:hnrnpd|HNRNPD]]|0.41|
|[[:human genes:l:lmo2|LMO2]]|0.409|
|[[:human genes:z:zbtb44|ZBTB44]]|0.407|
|[[:human genes:z:znf592|ZNF592]]|0.406|
|[[:human genes:m:med16|MED16]]|0.405|
|[[:human genes:s:sox7|SOX7]]|0.404|
|[[:human genes:m:mllt1|MLLT1]]|0.402|
|[[:human genes:d:dek|DEK]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7113
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCAF8 Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>