SCAF8
Gene Information
- Official Symbol: SCAF8
- Official Name: SR-related CTD associated factor 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 22828
- UniProt: Q9UPN6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in mRNA processing. {ECO:0000269|PubMed:11101529}.
Pfam Domains GO Terms
Pfam Domains
| RRM 1 |
| DUF618 |
GO Terms
| RNA polymerase core enzyme binding |
| negative regulation of termination of RNA polymerase II transcription |
| negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled |
| negative regulation of DNA-templated transcription, termination |
| regulation of termination of RNA polymerase II transcription, poly(A)-coupled |
| regulation of termination of RNA polymerase II transcription |
| RNA polymerase II C-terminal domain phosphoserine binding |
| regulation of DNA-templated transcription, termination |
| mRNA polyadenylation |
| RNA polyadenylation |
| positive regulation of DNA-templated transcription, elongation |
| RNA polymerase II complex binding |
| termination of RNA polymerase II transcription |
| regulation of DNA-templated transcription, elongation |
| negative regulation of protein complex disassembly |
| DNA-templated transcription, termination |
| mRNA 3-end processing |
| spliceosomal complex |
| nuclear matrix |
| regulation of protein complex disassembly |
| RNA 3-end processing |
| mRNA binding |
| RNA splicing |
| mRNA processing |
| transcription by RNA polymerase II |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| mRNA metabolic process |
| negative regulation of cellular component organization |
| negative regulation of transcription by RNA polymerase II |
| RNA processing |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ZNF410 | 0.522 |
| AGO2 | 0.508 |
| XPO6 | 0.495 |
| ID3 | 0.488 |
| ERG | 0.486 |
| SSBP2 | 0.475 |
| NSD1 | 0.471 |
| CELF1 | 0.462 |
| BAP1 | 0.451 |
| CCDC101 | 0.434 |
| IRF2BP2 | 0.432 |
| BRPF1 | 0.431 |
| PRKAR1A | 0.431 |
| RUNX1 | 0.43 |
| EGLN1 | 0.426 |
| DDX5 | 0.423 |
| ASXL2 | 0.423 |
| CBFB | 0.422 |
| MAML1 | 0.421 |
| MEF2C | 0.418 |
| TRIM28 | 0.414 |
| TLE4 | 0.41 |
| HNRNPD | 0.41 |
| LMO2 | 0.409 |
| ZBTB44 | 0.407 |
| ZNF592 | 0.406 |
| MED16 | 0.405 |
| SOX7 | 0.404 |
| MLLT1 | 0.402 |
| DEK | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7113
- Expression level (log2 read counts): 6.59
Expression Distribution
SCAF8 Expression in NALM6 Cells: 6.59
