SCAI

Gene Information

Official Symbol: SCAI
Official Name: suppressor of cancer cell invasion
Aliases and Previous Symbols: N/A
Entrez ID: 286205
UniProt: Q8N9R8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010].
UniProt Summary: Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. {ECO:0000269|PubMed:19350017}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9483
Expression level (log2 read counts): 6.11

Expression Distribution

Screen	Score
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-3.17
NFN1 1μM R03 exp100	-1.98
AICAR 240μM R03 exp116	1.76

negative regulation of Rho protein signal transduction
negative regulation of Ras protein signal transduction
negative regulation of small GTPase mediated signal transduction
regulation of Rho protein signal transduction
nuclear membrane
transcription corepressor activity
regulation of Ras protein signal transduction
negative regulation of cell migration
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
regulation of small GTPase mediated signal transduction
negative regulation of intracellular signal transduction
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of cell migration
regulation of cell motility
regulation of locomotion
regulation of cellular component movement
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of response to stimulus
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
regulation of intracellular signal transduction