SCAMP5

Entrez Summary: N/A
UniProt Summary: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. {ECO:0000269|PubMed:19234194}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of calcium ion-dependent exocytosis
regulation of calcium ion-dependent exocytosis
negative regulation of endocytosis
positive regulation of regulated secretory pathway
synaptic vesicle membrane
recycling endosome membrane
positive regulation of exocytosis
trans-Golgi network membrane
positive regulation of cytokine secretion
regulation of regulated secretory pathway
regulation of cytokine secretion
regulation of endocytosis
regulation of exocytosis
response to endoplasmic reticulum stress
protein-containing complex binding
positive regulation of protein secretion
positive regulation of peptide secretion
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of cytokine production
positive regulation of establishment of protein localization
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
cell junction
regulation of vesicle-mediated transport
Golgi membrane
regulation of cytokine production
negative regulation of cellular component organization
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
exocytosis
regulation of secretion
Golgi apparatus
positive regulation of transport
secretion by cell
regulation of protein localization